Erectile Dysfunction and Its Impact on Health-Related Quality of Life in Prostate Cancer Patients: A Multicenter Cross-Sectional Study from Pakistan.

[BACKGROUND/OBJECTIVES] Prostate cancer (PC) is one of the most commonly diagnosed malignancies globally; depending on the treatment strategy used, erectile dysfunction (ED) is a frequently reported adverse outcome among PC patients. The current study evaluated ED prevalence among Pakistani PC patients and its effects on physical, psychological, and social well-being, aiming to address critical gaps in survivorship care for this population.

[METHODS] A cross-sectional, multicenter, observational, questionnaire-based study was conducted in Rawalpindi and Islamabad, Pakistan, from February to April 2025. Health-related quality of life (HRQoL) among PC patients was measured using the Short Form Health Survey 36 (SF-36), while ED prevalence and severity were assessed by the International Index of Erectile Function (IIEF) instrument.

[RESULTS] Among = 400 PC patients, surgical treatments predominated (radical prostatectomy: 61.0%; = 244), while hormonal (androgen-deprivation therapy: 31.5%; = 126) and chemotherapy (23.3%; = 93) were also commonly utilized. ED experience was high among PC patients in the erectile function (40.8%; = 163) and in the intercourse satisfaction (45.0%; = 180) domains; these showed moderately strong and significant positive correlations across all SF-36 domains, particularly physical functioning (r = 0.52; < 0.001) and social functioning (r = 0.49; < 0.001). Regression analysis confirmed sexual function domains explained 60% of HRQoL variance (adjusted R = 0.60).

[CONCLUSIONS] This study reveals high rates of treatment-related ED-and its biopsychosocial impact-among Pakistani PC patients, with significant negative impacts on HRQoL. The findings underscore the urgent need to integrate sexual health management into standard oncological care practices to improve holistic patient outcomes.