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Unexpected 18 F-PSMA-1007 Uptake in a Colonic Diverticulum : A Benign Mimicker of Metastatic Prostate Cancer.

Clinical nuclear medicine 2026 Vol.51(2) p. 179-180

Zhang Z, Guo Z, Zuo C, Zhu L, Cheng C

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A 68-year-old man with rising PSA (0.363 ng/mL) 6 years post-prostatectomy underwent 18 F-PSMA-1007 PET/CT.

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BibTeX ↓ RIS ↓
APA Zhang Z, Guo Z, et al. (2026). Unexpected 18 F-PSMA-1007 Uptake in a Colonic Diverticulum : A Benign Mimicker of Metastatic Prostate Cancer.. Clinical nuclear medicine, 51(2), 179-180. https://doi.org/10.1097/RLU.0000000000006179
MLA Zhang Z, et al.. "Unexpected 18 F-PSMA-1007 Uptake in a Colonic Diverticulum : A Benign Mimicker of Metastatic Prostate Cancer.." Clinical nuclear medicine, vol. 51, no. 2, 2026, pp. 179-180.
PMID 41428836
DOI 10.1097/RLU.0000000000006179

Abstract

A 68-year-old man with rising PSA (0.363 ng/mL) 6 years post-prostatectomy underwent 18 F-PSMA-1007 PET/CT. The scan revealed rib metastasis and an unexpected PSMA-avid focus in the ascending colon. Previous 68 Ga-PSMA and subsequent 18 F-FDG PET both showed no abnormal uptake in the ascending colon area. Colonoscopy confirmed an ascending colon diverticulum. This rare case demonstrates intense 18 F-PSMA-1007 uptake in a colonic diverticulum, likely attributable to PSMA expression by neovascular endothelium or inflammatory cells. Clinicians should consider colonic diverticulum in the differential diagnosis of PSMA-avid colonic lesions to prevent misdiagnosis.

MeSH Terms

Humans; Male; Aged; Prostatic Neoplasms; Diagnosis, Differential; Positron Emission Tomography Computed Tomography; Diverticulum, Colon; Neoplasm Metastasis; Oligopeptides; Biological Transport; Niacinamide

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