Guo Z ⚠ 동명이인 가능성

Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of immune signaling and a target of high interest for immuno-oncology. Although numerous campaigns have been conducted to identify potent and selective HPK1 inhibitors, few en…

Following publication of the original article [...].…

[OBJECTIVE] Arsenic trioxide (ATO) is a cornerstone of acute promyelocytic leukemia (APL) therapy but induces severe gut microbiota dysbiosis, limiting its efficacy and safety. This study investigated whether adjunctive (BP) could mitigate…

[BACKGROUND] The overall survival rate of acute myeloid leukemia (AML) remains less than 30%. Metabolic reprogramming of leukemia cells, such as the Warburg effect, enables them to adapt to the microenvironment and thereby develop. Elucidat…

The modulation of immune checkpoint activity exerts profound impacts on tumor immunotherapy. However, the interfere of mature immune checkpoints encounter efficacy challenges in solid tumors, which underlies a critical barrier in clinical t…

Pancreatic cancer is one of the most common malignant tumors. Due to late diagnosis and a lack of effective treatments, pancreatic cancer has a poor prognosis and a high mortality rate. Further understanding of the mechanisms underlying the…

The intrinsic elasticity of the cell membrane-cortex complex, , the cell surface, is a promising biomarker for cell status and disease and has widespread biological and biomedical applications. However, measuring cell surface elasticity in …

Ferroptosis, a lipid peroxidation-driven form of regulated cell death, has emerged as a promising target for cancer therapy. However, the endogenous metabolic checkpoints restraining ferroptosis remain poorly defined. Here, we identify the …

[BACKGROUND] Metabolic‒epigenetic crosstalk critically orchestrates hepatocellular carcinoma (HCC) pathogenesis. Deciphering the precise mechanism underlying epigenetic remodeling and metabolic reprogramming in HCC may lead to novel treatme…

[BACKGROUND] Lung cancer is highly lethal because most patients have already developed metastases at diagnosis, yet the epigenetic mechanisms driving metastasis are unclear. [METHODS] We performed an epigenome-wide association study on 42 …

FLASH radiotherapy (FLASH-RT), with its ultra-high dose rate (≥40 Gy/s) that causes the "FLASH effect," significantly reduces normal tissue toxicity while maintaining tumor cytotoxicity, but its molecular mechanisms have not been fully eluc…

[INTRODUCTION] Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) has transformed the treatment of non-small cell lung cancer (NSCLC), yet acquired resistance remains a major challenge to its clinical efficacy. This revie…

Lung cancer remains the leading cause of cancer-related mortality worldwide, and immune checkpoint blockade is often limited by an immunosuppressive tumor microenvironment (TME). To address these challenges, we developed a novel multifuncti…

The global cancer burden continues to escalate, driven by a significant rise in new cases and cancer-related deaths. Early detection through effective screening programs is paramount for reducing mortality, and the integration of Artificial…

[BACKGROUND] Mitochondrial-related pathways (MRPs) play a crucial role in cancer metabolism and progression; however, their prognostic value in breast cancer (BC) is still poorly understood. [METHODS] We integrated multiomics data to inves…

Triple-negative breast cancer (TNBC) remains a formidable clinical challenge owing to its aggressive phenotype and limited treatment options. To address this, we employed ligand-based rational drug design coupled with scaffold hybridization…

Globally, colorectal cancer (CRC) ranks third in terms of incidence, while it is the second leading cause of cancer‑related mortality. The high incidence and mortality rates of CRC pose a considerable challenge to global human health. Curre…

[ETHNOPHARMACOLOGICAL RELEVANCE] Triple-negative breast cancer (TNBC) has a poor clinical prognosis and shows resistance to traditional treatments. Ferroptosis is a potential therapeutic strategy for TNBC. Although dandelion extract has dem…

Precise differential diagnosis between lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) and marginal zone lymphoma (MZL) remains a challenging issue because of overlapping clinicopathological and immunophenotypic features. …

This study aims to provide an overview of research hotspots and trends in KRAS, a key star gene which has been paid special attention to in the field of cancer. Publications on KRAS were searched in the Web of Science Core Collection databa…

Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive and lacks effective therapeutic options. Cancer cells frequently become more dependent on splicing factors than normal cells due to increased rates of transcription. Terminal urid…

Pancreatic ductal adenocarcinoma (PDAC) is the most malignant cancer and is characterized by short survival and limited treatment options. Epigenetic dysregulation is a defining feature of tumorigenesis but remains elusive in PDAC. Here, we…

[PURPOSE] Locally advanced thyroid cancer (LATC) presents significant surgical challenges, with a high risk of incomplete resection and poor prognosis. Patient-derived organoids (PDOs) are a powerful tool to assess drug sensitivity at an in…

[BACKGROUND] Gastric cancer is a prevalent malignancy worldwide, with early detection and treatment being vital to improving patient outcomes. Amino acids (AAs), as essential regulators in cancer cell metabolism, are implicated in the progr…

Hepatocellular carcinoma (HCC) is a serious concern worldwide. The published reports showed that aberrant CD95 receptor expression plays a critical role in apoptosis in liver cancer. While curcumin has shown promise in inducing apoptosis in…

To demonstrate the diagnostic and prognostic value of combined detection of serum abnormal prothrombin II (PIVKA II), α-fetoprotein (AFP), and spliced variants of hepatitis B virus genomes (spHBV) in HBV-induced hepatocellular carcinoma (HC…

Hepatocellular carcinoma (HCC) progression is driven by cancer stem cells (CSCs) with self-renewal and immune evasion capacities. Here, we identify a novel HIF-1α/YTHDF2/PFKL axis that orchestrates metabolic reprogramming in myeloid-derived…