Apalutamide-Induced Hypothyroidism Associated With Increased Thyroid Hormone Clearance in Metastatic Prostate Cancer Patient: A Case Report.
증례보고
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: a history of total thyroidectomy
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSION] Careful TSH monitoring is essential during APA treatment, especially in patients with pre-existing thyroid dysfunction or prior thyroidectomy. Appropriate levothyroxine titration and multidisciplinary collaboration are essential for the continuation of oncological therapy with APA.
[INTRODUCTION] Apalutamide (APA) is an androgen receptor signaling inhibitor widely used for metastatic hormone-sensitive prostate cancer (mHSPC), though it can induce hypothyroidism.
APA
Furumido J, Yamashita A, et al. (2026). Apalutamide-Induced Hypothyroidism Associated With Increased Thyroid Hormone Clearance in Metastatic Prostate Cancer Patient: A Case Report.. IJU case reports, 9(2), e70161. https://doi.org/10.1002/iju5.70161
MLA
Furumido J, et al.. "Apalutamide-Induced Hypothyroidism Associated With Increased Thyroid Hormone Clearance in Metastatic Prostate Cancer Patient: A Case Report.." IJU case reports, vol. 9, no. 2, 2026, pp. e70161.
PMID
41804321 ↗
Abstract 한글 요약
[INTRODUCTION] Apalutamide (APA) is an androgen receptor signaling inhibitor widely used for metastatic hormone-sensitive prostate cancer (mHSPC), though it can induce hypothyroidism. We report a severe case of APA-induced hypothyroidism in a patient with a history of total thyroidectomy.
[CASE PRESENTATION] A 65-year-old man receiving levothyroxine (175 μg/day) after thyroidectomy was diagnosed with mHSPC (Gleason score 4 + 4; PSA 13 904 ng/mL) with findings suggestive of cancer-associated disseminated intravascular coagulation. Following APA initiation (240 mg/day), PSA decreased rapidly to 0.01 ng/mL. However, TSH levels rose progressively despite increasing levothyroxine to 275 μg/day. After a 4-month follow-up interruption, TSH reached 187.9 mIU/L. APA withdrawal led to rapid TSH improvement.
[CONCLUSION] Careful TSH monitoring is essential during APA treatment, especially in patients with pre-existing thyroid dysfunction or prior thyroidectomy. Appropriate levothyroxine titration and multidisciplinary collaboration are essential for the continuation of oncological therapy with APA.
[CASE PRESENTATION] A 65-year-old man receiving levothyroxine (175 μg/day) after thyroidectomy was diagnosed with mHSPC (Gleason score 4 + 4; PSA 13 904 ng/mL) with findings suggestive of cancer-associated disseminated intravascular coagulation. Following APA initiation (240 mg/day), PSA decreased rapidly to 0.01 ng/mL. However, TSH levels rose progressively despite increasing levothyroxine to 275 μg/day. After a 4-month follow-up interruption, TSH reached 187.9 mIU/L. APA withdrawal led to rapid TSH improvement.
[CONCLUSION] Careful TSH monitoring is essential during APA treatment, especially in patients with pre-existing thyroid dysfunction or prior thyroidectomy. Appropriate levothyroxine titration and multidisciplinary collaboration are essential for the continuation of oncological therapy with APA.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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