Cancer Cell-Intrinsic Cholesterol Induces Lipid-Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression.
Cholesterol metabolism influences prostate cancer (PCa) progression, especially by affecting the tumor microenvironment.
APA
Peng S, Lin W, et al. (2026). Cancer Cell-Intrinsic Cholesterol Induces Lipid-Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression.. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 13(19), e08588. https://doi.org/10.1002/advs.202508588
MLA
Peng S, et al.. "Cancer Cell-Intrinsic Cholesterol Induces Lipid-Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression.." Advanced science (Weinheim, Baden-Wurttemberg, Germany), vol. 13, no. 19, 2026, pp. e08588.
PMID
41603134
Abstract
Cholesterol metabolism influences prostate cancer (PCa) progression, especially by affecting the tumor microenvironment. The present study demonstrated that cancer cell-intrinsic cholesterol promoted the S-palmitoylation of specificity protein 1 (SP1), enhancing SP1 nuclear translocation and driving the transcription and secretion of midkine (MDK), which in turn facilitated the differentiation of macrophages into a lipid-associated phenotype. Furthermore, targeting cholesterol metabolism with simvastatin significantly reduced MDK levels, inhibited immunosuppressive macrophage polarization, and enhanced the efficacy of enzalutamide in vivo. These findings suggested that targeting the cancer cell-intrinsic cholesterol-induced immunosuppressive tumor microenvironment could be an effective strategy to improve therapeutic outcomes in prostate cancer patients.
MeSH Terms
Male; Prostatic Neoplasms; Humans; Cholesterol; Animals; Macrophages; Sp1 Transcription Factor; Mice; Cell Differentiation; Disease Progression; Lipoylation; Tumor Microenvironment; Cell Line, Tumor; Lipid Metabolism; Benzamides
같은 제1저자의 인용 많은 논문 (5)
- Advances in Islet Function Replacing Strategies After Total Pancreatectomy.
- Nanozymes induced Z-scheme Mn-BiVO/Au/BiS heterostructure photoelectrochemical signal amplification for CA72-4 detection.
- RNA‑binding protein DAZAP1 promotes gastric cancer metastasis by enhancing NOTCH1 and JAG1 mRNA stability.
- Magnetic Resonance Guided Radiation Therapy (MRgRT) Prostate Motion and Margins.
- Ononin Inhibits the Growth and Metastasis of Hepatocellular Carcinoma by Suppressing MMP-2 and MMP-9 via PI3K/AKT/mTOR Signaling.