Air Pollution, Lifestyle, and Genetic Risk: A Multidimensional Study of PM Constituents and Prostate Cancer.
2/5 보강
TL;DR
Specific PM2.5 constituents, particularly NO3- and NH4+, are associated with an elevated prostate cancer risk, independent of genetic and lifestyle factors, and these findings suggest that public health interventions targeting air pollution sources and modifiable behaviors may help reduce disease burden.
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Air Quality and Health Impacts
Atmospheric chemistry and aerosols
Plant responses to elevated CO2
Specific PM2.5 constituents, particularly NO3- and NH4+, are associated with an elevated prostate cancer risk, independent of genetic and lifestyle factors, and these findings suggest that public heal
- 추적기간 13.7 years
APA
Feifei Zhang, Jie Zhou, et al. (2026). Air Pollution, Lifestyle, and Genetic Risk: A Multidimensional Study of PM Constituents and Prostate Cancer.. The Journal of urology, 215(5), 553-564. https://doi.org/10.1097/JU.0000000000004920
MLA
Feifei Zhang, et al.. "Air Pollution, Lifestyle, and Genetic Risk: A Multidimensional Study of PM Constituents and Prostate Cancer.." The Journal of urology, vol. 215, no. 5, 2026, pp. 553-564.
PMID
41528828 ↗
Abstract 한글 요약
[PURPOSE] To investigate the associations between long-term exposure to PM chemical constituents and incident prostate cancer, considering potential effect modification by genetic susceptibility and lifestyle.
[MATERIALS AND METHODS] We conducted a prospective study of 224,272 male participants from the UK Biobank with a median follow-up of 13.7 years. Individual exposures to PM and its 5 key constituents (SO, NO, NH, elemental carbon, and organic matter) were modeled. Prostate cancer incidence was ascertained through national cancer registries. We used Cox proportional hazard models to estimate associations, quantile g-computation for joint effects, and interaction analyses to evaluate effect modification by lifestyle and polygenic risk scores (PRS).
[RESULTS] High exposures to PM, SO, NO, and NH were significantly associated with increased prostate cancer risk, and NO showed the strongest association (HR per interquartile range: 1.088). The pollutant mixture had a positive joint effect, with NO contributing approximately 76.6% of this effect. Genetic predisposition, assessed by PRS, was a strong independent predictor of prostate cancer (HR for high vs low PRS: 6.527). No interaction effects were identified for the associations of lifestyle and PRS with PM constituents.
[CONCLUSIONS] Specific PM constituents, particularly NO and NH, are associated with an elevated prostate cancer risk, independent of genetic and lifestyle factors. These findings suggest that public health interventions targeting air pollution sources and modifiable behaviors may help reduce disease burden.
[MATERIALS AND METHODS] We conducted a prospective study of 224,272 male participants from the UK Biobank with a median follow-up of 13.7 years. Individual exposures to PM and its 5 key constituents (SO, NO, NH, elemental carbon, and organic matter) were modeled. Prostate cancer incidence was ascertained through national cancer registries. We used Cox proportional hazard models to estimate associations, quantile g-computation for joint effects, and interaction analyses to evaluate effect modification by lifestyle and polygenic risk scores (PRS).
[RESULTS] High exposures to PM, SO, NO, and NH were significantly associated with increased prostate cancer risk, and NO showed the strongest association (HR per interquartile range: 1.088). The pollutant mixture had a positive joint effect, with NO contributing approximately 76.6% of this effect. Genetic predisposition, assessed by PRS, was a strong independent predictor of prostate cancer (HR for high vs low PRS: 6.527). No interaction effects were identified for the associations of lifestyle and PRS with PM constituents.
[CONCLUSIONS] Specific PM constituents, particularly NO and NH, are associated with an elevated prostate cancer risk, independent of genetic and lifestyle factors. These findings suggest that public health interventions targeting air pollution sources and modifiable behaviors may help reduce disease burden.
🏷️ 키워드 / MeSH
- Male
- Humans
- Prostatic Neoplasms
- Particulate Matter
- Middle Aged
- Prospective Studies
- Life Style
- Air Pollution
- Genetic Predisposition to Disease
- Aged
- Incidence
- Environmental Exposure
- United Kingdom
- Air Pollutants
- Risk Factors
- Follow-Up Studies
- Risk Assessment
- ambient PM2.5
- ammonium
- elemental carbon
- organic matter
- prostate cancer
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