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Biliary disorders associated with immune checkpoint inhibitors: a pharmacovigilance analysis of the FDA adverse event reporting system (FAERS) database.
Immune checkpoint inhibitors (ICIs) are linked to severe biliary disorders (BDs). Using FAERS data (Q1 2015-Q1 2025), we identified 4,405 BD cases via standardized MedDRA queries (144 preferred terms). ICIs were significantly associated wit…
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Effect of electroacupuncture on postoperative delirium in elderly patients undergoing laparoscopic radical prostatectomy: study protocol for a double-center randomized controlled trial.
[BACKGROUND] Postoperative delirium (POD) is an acute disorder of attention and cognition, frequently observed as a complication in elderly individuals undergoing major surgery. Patients undergoing laparoscopic radical prostatectomy (LRP) a…
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Transforming colorectal health: A clinical diagnostic model for sessile serrated lesions detection.
ObjectiveThis study aimed to identify the clinical risk factors for colorectal sessile serrated lesions and to develop a diagnostic model to facilitate clinical diagnosis.MethodsPatients who underwent electronic colonoscopy during hospitali…
- Editorial: Treatment response and resistance to targeted therapies for NSCLC.
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Discovery and Validation of Lung Cancer Biomarkers Based on Proteomic Analysis of Bronchoalveolar Lavage Fluid from the Self-Controlled Pulmonary Lobes.
Distinguishing indeterminate pulmonary nodules remains a significant challenge in the early diagnosis of lung cancer. This study aims to identify lobe-specific proteomic biomarkers to address this issue. Using a data-independent acquisition…
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Profiling of the Golgi Apparatus Proteome in Living Cells Using Nanophotosensitizer-Mediated Photocatalytic Proximity Labeling.
Eukaryotic cells are characterized by a high degree of compartmentalization, wherein the function of proteins is intricately tied to their subcellular localization, as distinct compartments provide specialized microenvironments. The Golgi a…
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Endoplasmic reticulum stress in disease pathogenesis: its implications for therapy.
Endoplasmic reticulum (ER) stress is a key cellular mechanism that is important in the development of many diseases, including cancer. Since the discovery of the unfolded protein response (UPR), research has greatly improved our understandi…
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Transcriptomic and Epitranscriptomic Landscape of Integrated HTLV-1 in MT2 Cells.
Human T-lymphotropic virus type 1 (HTLV-1), the first human retrovirus identified, is linked to adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. However, its post-transcriptional regulation remains poorly…
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Ultrasensitive and multiplexed Gastric cancer biomarkers detection with an integrated electrochemical immunosensing platform.
Developing immunosensing platforms capable of simultaneously detecting multiple cancer markers is crucial for clinical diagnosis and biomedical research. Here, we introduce a novel dual-mode electrochemical biosensing assay platform capable…
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Exploring MAP3K genes in gastric cancer: biomarkers, tumor microenvironment dynamics, and chemotherapy resistance.
[BACKGROUND] Gastric cancer (GC) presents a significant global health burden, necessitating a deeper understanding of its molecular underpinnings for improved diagnostics and therapeutics. [METHODS] In this study, we investigated the expre…
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Real-world safety of Tepotinib: Insights from the Food and Drug Administration Adverse Event Reporting System.
[OBJECTS] Tepotinib is widely utilized for treating non-small cell lung cancer (NSCLC) patients with MET exon 14 (METex14) skipping mutations. The purpose of this study is to evaluate the safety characteristics of Tepotinib in the actual en…
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Advances in the Application of Microsurgical Techniques in Repairing Traumatic Auricular Defects.
[OBJECTIVES] Auricular reconstruction is one of the most challenging procedures in plastic surgery. However, traumatic auricular defects present more uncertainty and complexity than congenital microtia with various surgical options in auric…
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C118P Suppresses Gastric Cancer Growth via Promoting Autophagy-Lysosomal Degradation of RAB1A.
: Gastric cancer (GC) is the leading cause of cancer-related deaths worldwide. C118P, a microtubule inhibitor with anti-angiogenic and vascular-disrupting activities, was proven to be cytotoxic to various cancer cell lines. This study aimed…
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Application of Liposuction and Superior Pedicle Vertical Mammoplasty for Severe Breast Hypertrophy.
[BACKGROUND] Vertical mammoplasty techniques have been widely used for breast reduction. The authors present the combination of superior pedicle vertical mammoplasty with liposuction in different regions in the treatment of severe breast hy…
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Counterclockwise maxillomandibular advancement: a choice for Chinese patients with severe obstructive sleep apnea.
[PURPOSE] Maxillomandibular advancement (MMA) is an effective alternative for treating severe obstructive sleep apnea (OSA). However, the promotion of MMA in China is limited by many Chinese patients having a convex facial profile. To achie…