Clinical use of Zyplast in correction of age- and disease-related contour deficiencies of the face.

The authors present their experience with the use of Zyplast (glutaraldehyde crosslinked collagen) for the treatment of skin creases in the aging face, lip augmentation, scars, and facial atrophy. One hundred female patients were studied over a nine-month period. The results were found to be superior in some aspects compared with Zyderm II collagen, but there is loss of correction after six months and repeated "top-up" injections are needed every four to six months to maintain a satisfactory cosmetic correction. Zyplast collagen has not reduced the number of patient visits nor the cost of treatment.