Cell Polarity-related Gene PTK7, a Potential Diagnostic Biomarker in Pan-cancer.
[BACKGROUND] PTK7 (Protein Tyrosine Kinase 7), a member of the receptor protein tyrosine kinase family, was originally discovered in colon cancer cells.
APA
Zhang Y, Yan L, et al. (2025). Cell Polarity-related Gene PTK7, a Potential Diagnostic Biomarker in Pan-cancer.. Current medicinal chemistry, 32(33), 7327-7356. https://doi.org/10.2174/0109298673313999240816103054
MLA
Zhang Y, et al.. "Cell Polarity-related Gene PTK7, a Potential Diagnostic Biomarker in Pan-cancer.." Current medicinal chemistry, vol. 32, no. 33, 2025, pp. 7327-7356.
PMID
39253927
Abstract
[BACKGROUND] PTK7 (Protein Tyrosine Kinase 7), a member of the receptor protein tyrosine kinase family, was originally discovered in colon cancer cells. It plays a pivotal role in numerous developmental and physiological processes, particularly in the regulation of cell polarity. Despite accumulating evidence of PTK7's significant influence on tumor development, a comprehensive pan-cancer analysis of PTK7 has yet to be conducted.
[METHODS] We conducted a comprehensive analysis of PTK7's expression, prognostic value, and mutational patterns across various tumor types. We further explored the correlations between PTK7 expression and tumor stemness, immune-related genes, immune scores, and immune cell infiltration.
[RESULTS] Enrichment analysis revealed PTK7's critical involvement in pan-cancer functions and processes, including the WNT pathway, Epithelial-Mesenchymal Transition (EMT), and cell polarity regulation. Additionally, we validated PTK7's expression in gastric cancer via immunohistochemistry.
[CONCLUSION] Our study indicates that PTK7 holds promise as an ideal pan-cancer biomarker due to its involvement in tumor progression and tumor immunity.
[METHODS] We conducted a comprehensive analysis of PTK7's expression, prognostic value, and mutational patterns across various tumor types. We further explored the correlations between PTK7 expression and tumor stemness, immune-related genes, immune scores, and immune cell infiltration.
[RESULTS] Enrichment analysis revealed PTK7's critical involvement in pan-cancer functions and processes, including the WNT pathway, Epithelial-Mesenchymal Transition (EMT), and cell polarity regulation. Additionally, we validated PTK7's expression in gastric cancer via immunohistochemistry.
[CONCLUSION] Our study indicates that PTK7 holds promise as an ideal pan-cancer biomarker due to its involvement in tumor progression and tumor immunity.
MeSH Terms
Humans; Receptor Protein-Tyrosine Kinases; Biomarkers, Tumor; Cell Polarity; Neoplasms; Cell Adhesion Molecules; Epithelial-Mesenchymal Transition
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