Investigating the correlation between cytokine levels and prognostic factors in advanced gastric cancer: A systematic review and meta-analysis.
메타분석
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: and without metastasis (P = 0
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Further research is needed on the prognostic role of cytokines in AGC. [STUDY REGISTRATION] Prospero ID(CRD42024556571).
[BACKGROUND] Advanced gastric cancer (AGC) aggressiveness and poor prognosis necessitate understanding its molecular drivers.
- p-value P < 0.00001
APA
Shaibu Z, Yang F, et al. (2025). Investigating the correlation between cytokine levels and prognostic factors in advanced gastric cancer: A systematic review and meta-analysis.. Cancer treatment and research communications, 45, 101005. https://doi.org/10.1016/j.ctarc.2025.101005
MLA
Shaibu Z, et al.. "Investigating the correlation between cytokine levels and prognostic factors in advanced gastric cancer: A systematic review and meta-analysis.." Cancer treatment and research communications, vol. 45, 2025, pp. 101005.
PMID
41005104 ↗
Abstract 한글 요약
[BACKGROUND] Advanced gastric cancer (AGC) aggressiveness and poor prognosis necessitate understanding its molecular drivers. Cytokines in the tumor microenvironment influence tumor behavior, and this study aims to analyze their expression levels and correlate them with clinical outcomes in AGC patients to enhance prognostic understanding.
[METHOD] Original studies evaluating cytokine levels in AGC were searched in PubMed and Google Scholar databases up to October 31, 2023. Survival outcomes post-treatment, including five-year survival rates, were analyzed using RevMan 5.4.1, with a focus on OS, PFS, metastasis, and tumor stage for further evaluation.
[RESULTS] The results indicate a significant association between IL-17 and improved PFS in individuals with AGC (P < 0.00001). However, no statistically significant effects were observed for IL-2 (P = 0.22), IL-4 (P = 0.39), IL-10 (P = 0.22), IL-6 (P = 0.14), and IFN-gamma (P = 0.85), on PFS. Notably, IL-17 (P < 0.00001) and IL-6 (P < 0.00001) were found to have a substantial impact on OS in AGC patients. Conversely, the overall effect test did not show significance for IFN-gamma on OS (P = 0.95). Furthermore, there were no significant differences in IL-10 and IL-17 expression detected between AGC patients with and without metastasis (P = 0.64 and 0.11), nor in IL-6 levels between advanced (III-IV) and early stage (I-II) patients(P = 0.13).
[CONCLUSION] Elevated levels of IL-17 were linked to shorter PFS in AGC. Both IL-17 and IL-6 affected OS significantly, with higher levels associated with poorer OS outcomes, while other cytokines did not. Further research is needed on the prognostic role of cytokines in AGC.
[STUDY REGISTRATION] Prospero ID(CRD42024556571).
[METHOD] Original studies evaluating cytokine levels in AGC were searched in PubMed and Google Scholar databases up to October 31, 2023. Survival outcomes post-treatment, including five-year survival rates, were analyzed using RevMan 5.4.1, with a focus on OS, PFS, metastasis, and tumor stage for further evaluation.
[RESULTS] The results indicate a significant association between IL-17 and improved PFS in individuals with AGC (P < 0.00001). However, no statistically significant effects were observed for IL-2 (P = 0.22), IL-4 (P = 0.39), IL-10 (P = 0.22), IL-6 (P = 0.14), and IFN-gamma (P = 0.85), on PFS. Notably, IL-17 (P < 0.00001) and IL-6 (P < 0.00001) were found to have a substantial impact on OS in AGC patients. Conversely, the overall effect test did not show significance for IFN-gamma on OS (P = 0.95). Furthermore, there were no significant differences in IL-10 and IL-17 expression detected between AGC patients with and without metastasis (P = 0.64 and 0.11), nor in IL-6 levels between advanced (III-IV) and early stage (I-II) patients(P = 0.13).
[CONCLUSION] Elevated levels of IL-17 were linked to shorter PFS in AGC. Both IL-17 and IL-6 affected OS significantly, with higher levels associated with poorer OS outcomes, while other cytokines did not. Further research is needed on the prognostic role of cytokines in AGC.
[STUDY REGISTRATION] Prospero ID(CRD42024556571).
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