Design of an In Vitro Model for Epithelial-to-Mesenchymal Transition in Gastric Cancer.
1/5 보강
Epithelial-to-mesenchymal transition (EMT) is a developmental program that plays a vital role in gastric cancer, including aspects of tumor progression, the metastatic process, and resistance to treat
APA
Zhang Y, Bi L, et al. (2025). Design of an In Vitro Model for Epithelial-to-Mesenchymal Transition in Gastric Cancer.. Biochemical genetics, 63(1), 698-712. https://doi.org/10.1007/s10528-024-10668-x
MLA
Zhang Y, et al.. "Design of an In Vitro Model for Epithelial-to-Mesenchymal Transition in Gastric Cancer.." Biochemical genetics, vol. 63, no. 1, 2025, pp. 698-712.
PMID
38509423 ↗
Abstract 한글 요약
Epithelial-to-mesenchymal transition (EMT) is a developmental program that plays a vital role in gastric cancer, including aspects of tumor progression, the metastatic process, and resistance to treatment. Here, we have designed an in vitro model that mimics the features of EMT as observed in gastric cancer. The results showed that both migration and invasion were enhanced in gastric cancer cells with Brachyury overexpression. Additionally, the expression of IL-8 increased, while IL-8RA and IL-8RB levels significantly decreased in the in vitro model. Overall, the in vitro model offers an opportunity to study these phenomena relevant to EMT as they may occur in vivo in gastric cancer, as well as potential drug interactions that could interfere with these processes.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Epithelial-Mesenchymal Transition
- Stomach Neoplasms
- Humans
- Cell Line
- Tumor
- Cell Movement
- Brachyury Protein
- T-Box Domain Proteins
- Models
- Biological
- Interleukin-8
- Neoplasm Invasiveness
- Gene Expression Regulation
- Neoplastic
- Epithelial-to-mesenchymal transition
- Gastric cancer
- IL-8
- In vitro model
- Metastasis
같은 제1저자의 인용 많은 논문 (5)
- Comment on: "Interpretable machine learning model for predicting early recurrence of pancreatic cancer: integrating intratumoral and peritumoral radiomics with body composition".
- Blocking SHP2 benefits FGFR2 inhibitor and overcomes its resistance in -amplified gastric cancer.
- Impact of contrast-enhanced computed tomography surveillance frequency on survival outcomes in patients with stage I-III colorectal cancer: A propensity score-matched retrospective cohort study.
- Corrigendum to "TMEM176A drives anti-apoptotic signaling through TGM2-mediated ERK activation in gastric cancer" [Int. Immunopharmacol. 168 (2026) 115798].
- Dietary restriction genes as modulators of breast cancer risk through metabolic pathways.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Clinical Presentation and Outcomes of Patients Undergoing Surgery for Thyroid Cancer.
- Association of patient health education with the postoperative health related quality of life in low- intermediate recurrence risk differentiated thyroid cancer patients.