Ga-DOTA-FAPI-04 and F-FDG PET/CT: a head-to-head comparison for peritoneal carcinomatosis diagnostic accuracy.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
113 patients with suspected peritoneal malignancy, each of whom underwent Ga-FAPI and F-FDG PET/CT scans.
I · Intervention 중재 / 시술
Ga-FAPI and F-FDG PET/CT scans
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSIONS] Ga-FAPI has demonstrated superior diagnostic accuracy compared to F-FDG PET/CT in detecting PC with various types of cancer, particularly gastric cancer. Additionally, Ga-FAPI has shown significantly higher uptake and PCI score in PC compared to F-FDG, indicating its potential importance in clinical.
[PURPOSE] The study aimed to compare the diagnostic accuracy of Ga-DOTA-FAPI-04 (Ga-FAPI) and F-FDG PET/CT for peritoneal carcinomatosis (PC) in patients with various types of cancer.
- p-value P = 0.001
- p-value P < 0.001
APA
Chen X, Pang X, et al. (2025). Ga-DOTA-FAPI-04 and F-FDG PET/CT: a head-to-head comparison for peritoneal carcinomatosis diagnostic accuracy.. Abdominal radiology (New York), 50(7), 3137-3147. https://doi.org/10.1007/s00261-024-04653-6
MLA
Chen X, et al.. "Ga-DOTA-FAPI-04 and F-FDG PET/CT: a head-to-head comparison for peritoneal carcinomatosis diagnostic accuracy.." Abdominal radiology (New York), vol. 50, no. 7, 2025, pp. 3137-3147.
PMID
39751881 ↗
Abstract 한글 요약
[PURPOSE] The study aimed to compare the diagnostic accuracy of Ga-DOTA-FAPI-04 (Ga-FAPI) and F-FDG PET/CT for peritoneal carcinomatosis (PC) in patients with various types of cancer.
[METHODS] The study enrolled 113 patients with suspected peritoneal malignancy, each of whom underwent Ga-FAPI and F-FDG PET/CT scans. Lesions in all patients were confirmed through pathology or radiological follow-up. The evaluation and comparison of diagnostic performance, visual scores, maximum standardized uptake value (SUV), mean tumor-to-background ratio (TBR), and the peritoneal cancer index (PCI) score were conducted.
[RESULTS] Compared to F-FDG, Ga-FAPI PET/CT presented higher sensitivity, negative predictive value, and accuracy for detecting PC on a patient-level (100% vs. 93.2%, 100% vs. 22.22% and 93.81% vs. 86.73%, respectively). Semi-quantitative evaluation revealed that Ga-FAPI PET/CT had significantly higher SUV and TBR for PC [(6.06 ± 3.04 vs. 4.82 ± 2.75, P = 0.001) and (8.50 ± 5.01 vs. 2.92 ± 1.67, P < 0.001)]. The PCI score for PC was higher than the PCI score (11.28 ± 7.10 vs. 5.69 ± 5.15, P < 0.001).
[CONCLUSIONS] Ga-FAPI has demonstrated superior diagnostic accuracy compared to F-FDG PET/CT in detecting PC with various types of cancer, particularly gastric cancer. Additionally, Ga-FAPI has shown significantly higher uptake and PCI score in PC compared to F-FDG, indicating its potential importance in clinical.
[METHODS] The study enrolled 113 patients with suspected peritoneal malignancy, each of whom underwent Ga-FAPI and F-FDG PET/CT scans. Lesions in all patients were confirmed through pathology or radiological follow-up. The evaluation and comparison of diagnostic performance, visual scores, maximum standardized uptake value (SUV), mean tumor-to-background ratio (TBR), and the peritoneal cancer index (PCI) score were conducted.
[RESULTS] Compared to F-FDG, Ga-FAPI PET/CT presented higher sensitivity, negative predictive value, and accuracy for detecting PC on a patient-level (100% vs. 93.2%, 100% vs. 22.22% and 93.81% vs. 86.73%, respectively). Semi-quantitative evaluation revealed that Ga-FAPI PET/CT had significantly higher SUV and TBR for PC [(6.06 ± 3.04 vs. 4.82 ± 2.75, P = 0.001) and (8.50 ± 5.01 vs. 2.92 ± 1.67, P < 0.001)]. The PCI score for PC was higher than the PCI score (11.28 ± 7.10 vs. 5.69 ± 5.15, P < 0.001).
[CONCLUSIONS] Ga-FAPI has demonstrated superior diagnostic accuracy compared to F-FDG PET/CT in detecting PC with various types of cancer, particularly gastric cancer. Additionally, Ga-FAPI has shown significantly higher uptake and PCI score in PC compared to F-FDG, indicating its potential importance in clinical.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Positron Emission Tomography Computed Tomography
- Male
- Female
- Peritoneal Neoplasms
- Fluorodeoxyglucose F18
- Middle Aged
- Radiopharmaceuticals
- Aged
- Sensitivity and Specificity
- Adult
- Organometallic Compounds
- 80 and over
- Gallium Radioisotopes
- Retrospective Studies
- Coordination Complexes
- Quinolines
- 18F-FDG
- 68Ga-FAPI
- PET/CT
- Peritoneal cancer index
- Peritoneal carcinomatosis
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