Targeting fatty acid oxidation: A potential strategy for treating gastrointestinal tumors.
Gastrointestinal cancers including esophageal squamous cell carcinoma (ESCC), gastric cancer (GC), and colorectal cancer (CRC) are common and highly lethal types of cancer worldwide.
APA
Zheng Y, Jiang Z, et al. (2025). Targeting fatty acid oxidation: A potential strategy for treating gastrointestinal tumors.. International journal of cancer, 157(1), 7-17. https://doi.org/10.1002/ijc.35380
MLA
Zheng Y, et al.. "Targeting fatty acid oxidation: A potential strategy for treating gastrointestinal tumors.." International journal of cancer, vol. 157, no. 1, 2025, pp. 7-17.
PMID
40047558
Abstract
Gastrointestinal cancers including esophageal squamous cell carcinoma (ESCC), gastric cancer (GC), and colorectal cancer (CRC) are common and highly lethal types of cancer worldwide. Metabolic reprogramming plays a critical role in cancer progression and involves metabolic processes such as glucose and lipid metabolism. Fatty acid oxidation (FAO) has a profound impact on cancer, with many genes and cytokines influencing cancer cell initiation, development, metastasis, and resistance by regulating FAO. Additionally, FAO further promotes cancer progression by affecting the tumor microenvironment (TME). The role of FAO in gastrointestinal cancers has garnered increasing attention, and related anticancer drugs are currently being developed.
MeSH Terms
Humans; Fatty Acids; Gastrointestinal Neoplasms; Oxidation-Reduction; Tumor Microenvironment; Antineoplastic Agents; Lipid Metabolism; Animals
같은 제1저자의 인용 많은 논문 (5)
- Mentum, Mouth Floor, and Tongue Necrosis Following Hyaluronic Acid Injection for Chin Augmentation.
- Corrigendum to "Preparation of injectable temperature-sensitive chitosan-based hydrogel for combined hyperthermia and chemotherapy of colon cancer" [Carbohydrate Polymers 222 (2019) 115039].
- Arming Abraxane With Cationic Spermidine Conjugate and Homologous Cell Membrane for Enhanced Triple-Negative Breast Cancer Therapy.
- A rare case of successful treatmeat of xanthogranulomatous prostatitis and literature reviews.
- Mesenchymal stem cells inhibited chronic myeloid leukemia cells in vitro, correlating with oxidative stress.