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TNFAIP8L2 maintains hair cell function and regulates age-related hearing loss via mTORC1 signaling.
Age-related hearing loss (ARHL) is one of the most prevalent and complex disorders. Our previous study demonstrated that abnormal activation of mammalian target of rapamycin complex 1 (mTORC1) signaling in the cochlear neurosensory epitheli…
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Research Progress on the Detection Methods of Botulinum Neurotoxin.
Botulinum neurotoxins (BoNTs), produced by the anaerobic spore-forming bacterium Clostridium botulinum, are among the most potent known biological toxins. BoNTs cause lethal botulism via contaminated food, wound infections, or infant intest…
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Evaluation of a Cell-Based Potency Assay for Detection of the Potency of TrenibotulinumtoxinE (TrenibotE).
(1) Background: As an innovative drug derived from botulinum neurotoxin serotype E, TrenibotulinumtoxinE demonstrates a rapid onset and shorter effect. Due to concerns regarding specificity, test throughput, and animal welfare, a new cell-b…
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High-Frequency Ultrasound Imaging Findings for Different Breast Fillers.
[BACKGROUND] High-frequency ultrasound is commonly used for evaluating breast filling materials and can be used to diagnose adverse reactions after breast augmentation procedures. [METHODS] Breast ultrasound images obtained at the Plastic …
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Localization of the Submandibular Glands Using High-Frequency Ultrasound.
[BACKGROUND] Injecting botulinum toxin (BTX) into the submandibular glands (SMGs) can treat drooling symptoms in neurological diseases and improve the aesthetics of SMG hypertrophy and ptotic SMGs. [OBJECTIVES] This study aimed to define t…
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A Validation of the Equivalence of the Cell-Based Potency Assay Method with a Mouse LD Bioassay for the Potency Testing of OnabotulinumtoxinA.
(1) Background: At present, the only potency assay approved in China for the in-country testing of botulinum toxin type A for injection products is the mouse bioassay (MBA). The Chinese market for neurotoxin products is rapidly expanding, b…
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A Comparison of Plastic Surgery Authorship Trends Under Single Versus Double-Blinded Review.
[INTRODUCTION] Research is key to academic advancement in plastic surgery. However, access to publication opportunities may be inequitable as seen in other fields. We compared authorship trends of plastic surgery manuscripts that underwent …
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Clinical application of double V-Y advancement mucosal flap to repair tongue defect.
[OBJECTIVES] The repair of small- and medium-sized defects in the oral tongue has always been a challenge, and the effect of free flap and distal pedicle flap is still far from satisfactory. Tongue flap is an ideal choice for repairing smal…
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Soft and stretchable organic bioelectronics for continuous intraoperative neurophysiological monitoring during microsurgery.
In microneurosurgery, it is crucial to maintain the structural and functional integrity of the nerve through continuous intraoperative identification of neural anatomy. To this end, here we report the development of a translatable system le…
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Efficacy of botulinum-A for nocturnal bruxism pain and the occurrence of bruxism events: a meta-analysis and systematic review.
The purpose of this study was to explore the treatment efficacy of botulinum-A (BTX-A) in nocturnal bruxism. Five electronic databases (PubMed, Web of Science, Cochrane, Embase and Clinical Trials) were searched to identify related randomis…
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A Novel Imaging Grading Biomarker for Predicting Hearing Loss in Acoustic Neuromas.
[PURPOSE] The aim of this study was to investigate an imaging biomarker based on contrast enhanced T1-weighted and T2-weighted magnetic resonance imaging (MRI) to determine the hearing loss related to acoustic neuromas (AN). [METHODS] In t…
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Percutaneous Full-Endoscopic C2 Ganglionectomy for the Treatment of Intractable Occipital Neuralgia: Technical Note.
[BACKGROUND] The C-2 dorsal root ganglionectomy procedure can provide effective treatment for intractable occipital neuralgia (ON). However, the traditional microsurgery of C2 ganglionectomy needs a wide incision and significant paraspinous…