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Unraveling the role of PREX2 mutations as a biomarker for immunotherapy response in colorectal cancer.

1/5 보강

Cancer biomarkers : section A of Disease markers 📖 저널 OA 85.7% 2023~2026 2025 Vol.42(9) p. 18758592251380454

PICO 자동 추출 (휴리스틱, conf 2/4)

유사 논문

P · Population 대상 환자/모집단

1764 patients (1385 colorectal, 379 gastric), NGS of 639 genes and PD - L1 staining were done.

I · Intervention 중재 / 시술

추출되지 않음

C · Comparison 대조 / 비교

추출되지 않음

O · Outcome 결과 / 결론

In gastric cancer, there are no established immune associations with PREX2 mutations.ConclusionPREX2 mutations may serve as a novel predictive biomarker for immunotherapy in CRC, potentially enhancing antitumor immunity via microenvironment modulation, but lack predictive value in GC. These findings highlight PREX2's role in refining patient stratification for immune checkpoint inhibitors.

Peng H, Yang P, Wang X, Zhao X, Li J, Gong Z

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

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