Exploring the mechanism of daphne-type diterpenes against gastric cancer cells.
1/5 보강
Gastric cancer is one of the common malignant tumors.
APA
Wang YJ, Wang XY, et al. (2025). Exploring the mechanism of daphne-type diterpenes against gastric cancer cells.. Journal of Asian natural products research, 27(12), 1836-1848. https://doi.org/10.1080/10286020.2024.2311149
MLA
Wang YJ, et al.. "Exploring the mechanism of daphne-type diterpenes against gastric cancer cells.." Journal of Asian natural products research, vol. 27, no. 12, 2025, pp. 1836-1848.
PMID
38347741 ↗
Abstract 한글 요약
Gastric cancer is one of the common malignant tumors. It is reported that daphne-type diterpenes have inhibitory effects on gastric cancer cells, but the mechanism is still unknown. To explore the detailed mechanism of the anticancer effect of daphne-type diterpenes, we carried out an integrated network pharmacology prediction study and selected an effective component (yuanhuacine, YHC) for the following validation and . The result showed that daphne-type diterpenes exerted an anti-tumor effect by targeting proto-oncogene tyrosine-protein kinase SRC as well as regulating the Ras/MAPK signaling pathway, which caused the apoptosis and mitochondrial damage in gastric cancer cells.
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