The LGALS9/miR-491-5p Axis Regulates CD8 T Cell Function and Inhibits the Progression of Gastric Cancer.
1/5 보강
Gastric cancer is a prevalent and clinically significant gastrointestinal malignancy worldwide.
APA
Huang W, Zheng W, et al. (2026). The LGALS9/miR-491-5p Axis Regulates CD8 T Cell Function and Inhibits the Progression of Gastric Cancer.. Cancer science, 117(1), 50-62. https://doi.org/10.1111/cas.70232
MLA
Huang W, et al.. "The LGALS9/miR-491-5p Axis Regulates CD8 T Cell Function and Inhibits the Progression of Gastric Cancer.." Cancer science, vol. 117, no. 1, 2026, pp. 50-62.
PMID
41171621 ↗
Abstract 한글 요약
Gastric cancer is a prevalent and clinically significant gastrointestinal malignancy worldwide. Gastric cancer is characterized by limited treatment efficacy and a high recurrence rate. In this study, we found that LGALS9 was highly expressed in gastric cancer and may contribute to disease progression by modulating the infiltration of CD8 T cells. Genetic knockout of LGALS9 reversed T cell function, attenuated immunosuppression, and enhanced the cytotoxic activity of T cells to kill gastric cancer cells. Furthermore, miR-491-5p was identified as a potential suppressor in gastric cancer. The microRNA miR-491-5p regulated T cell-mediated immunity by targeting and inhibiting LGALS9, which was similar to the effect of LGALS9 knockout. Overall, the key target LGALS9 and its inhibitor miR-491-5p represent promising potential for treating gastric cancer.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
같은 제1저자의 인용 많은 논문 (5)
- PSMA PET-directed radiotherapy for prostate cancer: From precision planning to future innovations.
- B-cell lymphoblastic lymphoma masquerading as primary dacryocystitis: A case report.
- Chemical anchoring of immunotherapeutic drugs within senescent tumor cells overcomes senescence-driven immunotherapy resistance.
- Sparse robust discriminant analysis for high-dimensional and heavy-tailed data.
- The relationship between sleep disturbances, depression and anxiety in differentiated thyroid cancer patients during radioiodine (131I) therapy: a longitudinal observational study.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Association of patient health education with the postoperative health related quality of life in low- intermediate recurrence risk differentiated thyroid cancer patients.
- Early local immune activation following intra-operative radiotherapy in human breast tissue.