-derived methionine promotes gastric cancer progression.
[BACKGROUND] has been linked with an increasing risk of gastric cancer (GC) and recognised as a signature for GC screening.
APA
Zhou CB, Zhao LC, et al. (2026). -derived methionine promotes gastric cancer progression.. Gut. https://doi.org/10.1136/gutjnl-2025-336966
MLA
Zhou CB, et al.. "-derived methionine promotes gastric cancer progression.." Gut, 2026.
PMID
41482458
Abstract
[BACKGROUND] has been linked with an increasing risk of gastric cancer (GC) and recognised as a signature for GC screening.
[OBJECTIVE] To investigate the promotional effect of in terms of its metabolic interactions with the host.
[DESIGN] We used the functional profiles of shotgun metagenomic sequencing from stools to detect bioactive molecules relevant to . In vivo and in vitro experiments were used to validate the facilitation of to GC progression. clinical strains were isolated and cultivated from cancerous tissues to verify its promotion of GC via methionine production. mutant strains were constructed to confirm the critical role of in methionine biosynthesis.
[RESULTS] We verified facilitated GC progression in vivo and in vitro. Our functional analysis of metagenomes revealed a significant enrichment of bacterial methionine biosynthesis pathways in GC patients with high abundance. Methionine, identified here as one of the primary microbial metabolites derived from contributed to GC progression in humans and mice. strains from cancerous tissues were found to promote GC via methionine production. We further observed a higher abundance and prevalence of gene in cancer stool metagenomes. By constructing an mutant strain, we confirmed the critical role of in methionine biosynthesis.
[CONCLUSION] Our results elucidate the role of -derived methionine in GC progression, shedding light on intricate metabolic interplay between and host.
[OBJECTIVE] To investigate the promotional effect of in terms of its metabolic interactions with the host.
[DESIGN] We used the functional profiles of shotgun metagenomic sequencing from stools to detect bioactive molecules relevant to . In vivo and in vitro experiments were used to validate the facilitation of to GC progression. clinical strains were isolated and cultivated from cancerous tissues to verify its promotion of GC via methionine production. mutant strains were constructed to confirm the critical role of in methionine biosynthesis.
[RESULTS] We verified facilitated GC progression in vivo and in vitro. Our functional analysis of metagenomes revealed a significant enrichment of bacterial methionine biosynthesis pathways in GC patients with high abundance. Methionine, identified here as one of the primary microbial metabolites derived from contributed to GC progression in humans and mice. strains from cancerous tissues were found to promote GC via methionine production. We further observed a higher abundance and prevalence of gene in cancer stool metagenomes. By constructing an mutant strain, we confirmed the critical role of in methionine biosynthesis.
[CONCLUSION] Our results elucidate the role of -derived methionine in GC progression, shedding light on intricate metabolic interplay between and host.