Risk Factors for Body Weight Loss After Gastrectomy for Gastric Cancer Analyzed From the JCOG1001 Phase III Trial.
[AIM] To investigate the factors associated with BWL after gastrectomy using data from the phase III trial (JCOG1001).
- 95% CI 2.291-4.617
APA
Yamada T, Kurokawa Y, et al. (2026). Risk Factors for Body Weight Loss After Gastrectomy for Gastric Cancer Analyzed From the JCOG1001 Phase III Trial.. Annals of gastroenterological surgery, 10(2), 452-459. https://doi.org/10.1002/ags3.70123
MLA
Yamada T, et al.. "Risk Factors for Body Weight Loss After Gastrectomy for Gastric Cancer Analyzed From the JCOG1001 Phase III Trial.." Annals of gastroenterological surgery, vol. 10, no. 2, 2026, pp. 452-459.
PMID
41799571
Abstract
[AIM] To investigate the factors associated with BWL after gastrectomy using data from the phase III trial (JCOG1001).
[METHODS] This post hoc analysis included 728 patients from the JCOG1001. The percentage of BWL (%BWL) was defined as the proportion of decrease in body weight immediately before adjuvant chemotherapy initiation compared with that before surgery. Background, surgery, and postoperative data were compared between patients with and without a %BWL ≥ 10. The impact of each factor for a %BWL ≥ 10 was calculated using logistic regression analysis.
[RESULTS] %BWL ≥ 10 was observed in 258 (35.4%) patients. Male sex, preoperative body mass index (BMI) ≥ 25, total gastrectomy, operation time ≥ 238 min, intraoperative blood loss ≥ 285 mL, and postoperative complications were more frequent among patients with %BWL ≥ 10. Using multivariable analysis, a preoperative BMI ≥ 25 (odds ratio [OR] 1.870, 95% confidence interval [CI] 1.267-2.762, < 0.01), total gastrectomy (vs. distal) (OR 3.252, 95% CI 2.291-4.617, < 0.01), and grade 2-4 postoperative complications (vs. grade 0-1) (OR 3.229, 95% CI 2.192-4.756, < 0.01) were independent risk factors for a %BWL ≥ 10.
[CONCLUSION] High preoperative BMI, total gastrectomy, and/or postoperative complications were risk factors for postoperative BWL ≥ 10% after gastrectomy for gastric cancer.
[TRIAL REGISTRATION] The JCOG1001 was registered with UMIN-CTR, under the number UMIN000003688.
[METHODS] This post hoc analysis included 728 patients from the JCOG1001. The percentage of BWL (%BWL) was defined as the proportion of decrease in body weight immediately before adjuvant chemotherapy initiation compared with that before surgery. Background, surgery, and postoperative data were compared between patients with and without a %BWL ≥ 10. The impact of each factor for a %BWL ≥ 10 was calculated using logistic regression analysis.
[RESULTS] %BWL ≥ 10 was observed in 258 (35.4%) patients. Male sex, preoperative body mass index (BMI) ≥ 25, total gastrectomy, operation time ≥ 238 min, intraoperative blood loss ≥ 285 mL, and postoperative complications were more frequent among patients with %BWL ≥ 10. Using multivariable analysis, a preoperative BMI ≥ 25 (odds ratio [OR] 1.870, 95% confidence interval [CI] 1.267-2.762, < 0.01), total gastrectomy (vs. distal) (OR 3.252, 95% CI 2.291-4.617, < 0.01), and grade 2-4 postoperative complications (vs. grade 0-1) (OR 3.229, 95% CI 2.192-4.756, < 0.01) were independent risk factors for a %BWL ≥ 10.
[CONCLUSION] High preoperative BMI, total gastrectomy, and/or postoperative complications were risk factors for postoperative BWL ≥ 10% after gastrectomy for gastric cancer.
[TRIAL REGISTRATION] The JCOG1001 was registered with UMIN-CTR, under the number UMIN000003688.
같은 제1저자의 인용 많은 논문 (5)
- Persistent SARS-CoV-2 Infection in an Immunocompromised Host Treated Successfully With the Japanese Herbal Medicine, Mao-to: A Case Report.
- Post-transplant hepatocellular carcinoma: balancing immunosuppression and immune checkpoint inhibitors.
- Ergothioneine Attenuates Oxaliplatin-Induced Peripheral Neuropathy Without Compromising Antitumor Efficacy.
- Impact of extended prophylactic antibiotic administration on surgical site infections: A multicenter real-world data study.
- Comparison of Clinical Outcomes Between Delta-Shaped and Circular Anastomoses After Laparoscopic Distal Gastrectomy.