A 15-layer multi-omics analysis of gastric cancer ecotypes provides therapeutic insights.
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OpenAlex 토픽 ·
Gastric Cancer Management and Outcomes
Ferroptosis and cancer prognosis
Cancer Genomics and Diagnostics
Gastric cancer is marked by profound molecular and microenvironmental heterogeneity that limits therapeutic progress.
APA
Yuefan Wang, Lindsey K. Olsen, et al. (2026). A 15-layer multi-omics analysis of gastric cancer ecotypes provides therapeutic insights.. Cell reports. Medicine, 102756. https://doi.org/10.1016/j.xcrm.2026.102756
MLA
Yuefan Wang, et al.. "A 15-layer multi-omics analysis of gastric cancer ecotypes provides therapeutic insights.." Cell reports. Medicine, 2026, pp. 102756.
PMID
42013851 ↗
Abstract 한글 요약
Gastric cancer is marked by profound molecular and microenvironmental heterogeneity that limits therapeutic progress. Here, we present a 15-layer multi-omics atlas that integrates genomics, epigenomics, transcriptomics, proteomics, multiple post-translational modifications (PTMs), protein-protein interactions, metabolomics, and microbiome profiles from 159 primary gastric adenocarcinomas and 30 matched normal adjacent tissues. Using cell-state deconvolution, we define tumor ecotypes that refine genomic and histological subtypes by capturing distinct tumor microenvironment architectures linked to clinical outcomes and potential associations with immunotherapy response. Multi-omics integration prioritizes genomic and epigenomic aberrations and their associated vulnerabilities; defines ecotype-specific transcriptional programs, signaling pathways, PTMs, protein interaction networks, and metabolic regulation; and identifies microbiome features linked to ecotypes and resistance pathways. We further prioritize ecotype-, genomic subtype-, and cell type-specific targetable proteins using proteomic and PTM analyses within a tumor microenvironment context. This comprehensive atlas provides a systems-level blueprint for decoding gastric cancer heterogeneity and advancing precision oncology.
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