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A mitochondria-targeted sequence-activated fluorescent probe responsive to HO and viscosity for imaging and surgical navigation of hepatocellular carcinoma.

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Chemical communications (Cambridge, England) 📖 저널 OA 0% 2024: 0/1 OA 2025: 0/6 OA 2026: 0/24 OA 2024~2026 2025 Vol.61(73) p. 13924-13927
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Zhang W, Sheng Y, Zhang M, Wang Q, Wang X, Wang H

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A mitochondria-targeted fluorescent probe (HV) sequentially activated by HO and viscosity was constructed.

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APA Zhang W, Sheng Y, et al. (2025). A mitochondria-targeted sequence-activated fluorescent probe responsive to HO and viscosity for imaging and surgical navigation of hepatocellular carcinoma.. Chemical communications (Cambridge, England), 61(73), 13924-13927. https://doi.org/10.1039/d5cc03664j
MLA Zhang W, et al.. "A mitochondria-targeted sequence-activated fluorescent probe responsive to HO and viscosity for imaging and surgical navigation of hepatocellular carcinoma.." Chemical communications (Cambridge, England), vol. 61, no. 73, 2025, pp. 13924-13927.
PMID 40814830 ↗
DOI 10.1039/d5cc03664j

Abstract

A mitochondria-targeted fluorescent probe (HV) sequentially activated by HO and viscosity was constructed. Probe HV exhibits high specificity and excellent biocompatibility. Due to the upregulation of mitochondrial HO and viscosity in cancer cells, HV is capable of illuminating hepatocellular carcinoma. HV surpasses the limitations of single-marker detection of liver cancer and enables powerful imaging-guided hepatic cancer resections, improving the precision of liver diagnosis and treatment.

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