Chitosan-coated boronic acid modified magnetic alginate microbeads: dual encapsulation and release of 5-fluorouracil and resveratrol.
1/5 보강
In this study, it was aimed to develop magnetic microbeads for dual delivery of 5-Fluorouracil (5-FU) and Resveratrol (RES).
APA
Yavaşer Boncooğlu R, Yalçin Bingül D (2025). Chitosan-coated boronic acid modified magnetic alginate microbeads: dual encapsulation and release of 5-fluorouracil and resveratrol.. Journal of biomaterials science. Polymer edition, 1-20. https://doi.org/10.1080/09205063.2025.2564679
MLA
Yavaşer Boncooğlu R, et al.. "Chitosan-coated boronic acid modified magnetic alginate microbeads: dual encapsulation and release of 5-fluorouracil and resveratrol.." Journal of biomaterials science. Polymer edition, 2025, pp. 1-20.
PMID
41003680 ↗
Abstract 한글 요약
In this study, it was aimed to develop magnetic microbeads for dual delivery of 5-Fluorouracil (5-FU) and Resveratrol (RES). FeO nanoparticles were coated with alginate, modified with 3-aminophenylboronic acid (APBA) by carbodiimide chemistry, gelled with CaCl, and coated with chitosan after drug loading by swelling method. FTIR, TEM, SEM, ESR, and XRD were used for characterization. Microbeads were further investigated for entrapment efficiency (EE), swelling analysis, release, and cytotoxicity. Entrapment efficiencies were 62.2 ± 0.78 and 27.1 ± 0.98% w/w for 5-FU and RES, respectively. Drug release was studied at pH 1.5, 5.5, 6.8, and 7.4. Microbeads exhibited the highest release at pH 6.8 (65.3 ± 2.50% w/w for 5-FU and 45.4 ± 1.80% w/w for RES). Release kinetics conformed to Higuchi model at pH 6.8 and Korsmeyer-Peppas at pHs 5.5 and 7.4. Microbeads containing 300 µg/mL drug reduced cell viability of HT-29 colon cancer cell line below 50% in cytotoxicity experiments.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- Cell Line-Dependent Cell Death Pathways Induced by Thymoquinone in Colorectal Cancer Cells.
- Microfluidic Encapsulation of Sorafenib-Loaded ZIF-8 Nanoparticles in pH-Responsive Alginate Microparticles for Oral Chemotherapy of Hepatocellular Carcinoma.
- PrP-Neutralizing Antibody Confers an Additive Benefit in Combination with 5-Fluorouracil in KRAS-Mutant Colorectal Cancer Models, Associated with Reduced RAS-GTP and AKT/ERK Phosphorylation.
- Metal-ion-coordinated silk fibroin nanogels for enhanced oral chemotherapy of colorectal cancer.
- Exceptional long-term survival in a patient with recurrent pancreatic carcinoma on adjuvant tegafur-gimeracil-oteracil potassium: a case report.
- Aronia Berry Extract Inhibits Cancer Stemness and Overcomes 5-Fluorouracil Resistance by Targeting TLR3/NF-κB Signaling in Colorectal Cancer.