Aspidosperma-type bisindole alkaloids from Melodinus suaveolens and their antiproliferative activities.
1/5 보강
Melosuadimins A-L (1-12), twelve undescribed monoterpenoid dimeric alkaloids with different subsets of aspidosperma-type alkaloid units were isolated from Melodinus suaveolens.
APA
Wu J, Wu W, et al. (2025). Aspidosperma-type bisindole alkaloids from Melodinus suaveolens and their antiproliferative activities.. Phytochemistry, 238, 114556. https://doi.org/10.1016/j.phytochem.2025.114556
MLA
Wu J, et al.. "Aspidosperma-type bisindole alkaloids from Melodinus suaveolens and their antiproliferative activities.." Phytochemistry, vol. 238, 2025, pp. 114556.
PMID
40412711 ↗
Abstract 한글 요약
Melosuadimins A-L (1-12), twelve undescribed monoterpenoid dimeric alkaloids with different subsets of aspidosperma-type alkaloid units were isolated from Melodinus suaveolens. Their structures were elucidated through extensive spectroscopic data analysis. Notably, melosuadimin A (1) was a vindoline-aspidosperma type bisindole alkaloid with a dihydrofuran ring linkage. Melosuadimins B (2) and C (3) were proposed as oxidation and ring-opening derivatives of melosuadimin A. Additionally, melosuadimin D (4), featuring a unique 1,2-oxazinane ring, was possibly produced through rearrangement from melosuadimin B. The in vitro cytotoxic potential of these compounds against three colorectal cancer cell lines was evaluated, revealing that 2 exhibited marked antiproliferative activity, inducing apoptosis and G2/M cell cycle arrest.
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