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Comparison of induction chemotherapy with/without PD-1 inhibitors followed by concurrent chemoradiotherapy in locally advanced head and neck squamous cell carcinoma.
[BACKGROUND] Locally advanced head and neck squamous cell carcinoma (LA HNSCC) remains a disease with a challenging prognosis. Concurrent chemoradiotherapy has long been the standard of care, yet efforts to enhance outcomes through the addi…
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Multi-omics approaches for identifying the PANoptosis signature and prognostic model via a multimachine-learning computational framework for intrahepatic cholangiocarcinoma.
[BACKGROUND AND AIMS] The aims of the present study were to characterize the PANoptosis signature in intrahepatic cholangiocarcinoma (ICC) patients, construct a novel model to guide clinical diagnosis and treatment, and further explore the …
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IFN-γ Driven Hepatic Injury Exacerbates Mortality in NK/T-Cell Lymphoma-Associated Hemophagocytic Lymphohistiocytosis.
[BACKGROUND] Hepatic involvement is a life-threatening complication in natural killer/T-cell lymphoma with hemophagocytic lymphohistiocytosis (NK/T-HLH). Nevertheless, the prognostic implications of hepatic dysfunction and its underlying re…
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Cross-kingdom miRNA delivery by Panax notoginseng-derived extracellular-like nanoparticles vesicles restores neuronal function after ischemic injury.
Blood-brain barrier (BBB) impermeability remains a major obstacle to the effective treatment of neurological disorders, particularly ischemic stroke. Here, we revealed that plant-derived extracellular vesicle-like nanoparticles (PEVs) offer…
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Development and validation of the ultrasound-based radiomics and deep learning prognostic models for diffuse large B-cell lymphoma.
Lymphoma includes fatal hematological malignancies, with diffuse large B-cell lymphoma (DLBCL) as the most common aggressive non-Hodgkin lymphoma subtype. Accurate early identification of high-risk DLBCL patients is key for individualized t…
- Mycosis fungoides.
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Exposure to per- and polyfluoroalkyl substance (PFAS) mixtures increases papillary thyroid cancer risk and clinicopathological aggressiveness: Findings from a case-control study and risk assessment.
Per- and polyfluoroalkyl substances (PFAS) have been reported to possess endocrine-disrupting and tumor-promoting activity. However, the association between PFAS exposure and papillary thyroid carcinoma (PTC) remains poorly understood. This…
- The value of multiparametric magnetic resonance imaging in the prognostic judgment of prostate cancer.
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A Bibliometric Analysis of Research Trends and Collaborative Networks in Gastric Cancer and Helicobacter Pylori Studies.
[BACKGROUND] Gastric cancer (GC) remains a significant global health burden, with Helicobacter pylori (H. pylori) infection being a major etiological factor. Despite extensive research, a comprehensive overview of the temporal evolution of …
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Remimazolam impairs bone marrow mesenchymal stem cell function and attenuates the tumor-promoting ability.
Bone marrow mesenchymal stem cells (BMMSCs) possess the potential for multidirectional differentiation and are involved in tissue regeneration, repair, and tumor progression. Remimazolam is a novel ultra-short-acting intravenous benzodiazep…
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Synergistic Strategies in Systemic Therapy for Advanced Hepatocellular Carcinoma.
Hepatocellular carcinoma (HCC) remains the most prevalent primary liver cancer, characterized by alarmingly high mortality rates and low five-year survival outcomes. A significant challenge in HCC management lies in its advanced-stage treat…
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MRI-based radiomics with automated segmentation and manual refinement for predicting treatment response in unresectable hepatocellular carcinoma: a multicenter study.
[OBJECTIVE] To compare the effect of different segmentation strategies on the performance of multiparametric MRI-based radiomics models for predicting response to combined therapy in unresectable hepatocellular carcinoma (HCC). [METHODS] T…
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Identification of super-enhancer-based biomarkers for predicting survival and immunotherapy efficacy in colorectal cancer.
Immune checkpoint inhibitors are effective treatments for many tumors. However, existing biomarkers can benefit only a small selection of colorectal cancer patients. Super-enhancers are associated with various tumor characteristics. We wond…
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Synchronous sequential combination of transarterial chemoembolization and microwave ablation for hepatocellular carcinoma: Efficacy and prognosis.
[BACKGROUND] Despite therapeutic advances, outcomes in hepatocellular carcinoma (HCC) remain suboptimal, underscoring the need to explore more effective treatment strategies. [AIM] To compare efficacy and prognosis in HCC patients treated …
- Differential prognostic impact of liver resection by the site of concurrent extrahepatic diseases in patients with colorectal cancer liver metastases: a nationwide multicenter study (correspondence).
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Proteome profiling reveals early diagnostic biomarker candidates for colorectal cancer.
[BACKGROUND] Colorectal cancer (CRC) is the third most common cancer worldwide. Advanced CRC has a grim prognosis, so there is a high demand for an early non-invasive diagnostic biomarker. [METHODS] We present a colorectal tissue-serum pro…
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MMP14 is a safe target of CAR-T therapy against liver cancer and metastasis.
[BACKGROUND] Hepatocellular carcinoma (HCC) is one of the most lethal tumors, and effective treatments for HCC, especially metastatic HCC, are lacking. Chimeric antigen receptor (CAR)-T-cell therapy is considered a promising development in …
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NUDT21-mediated Alternative Polyadenylation of CDK19 Reprograms Cholesterol Biosynthesis to Drive Colorectal Cancer Progression.
Alternative polyadenylation (APA) is critical for shaping transcriptome diversity by generating mRNA isoforms that differ in the length of their 3'untranslated region (3'UTR). APA dysregulation, a defined feature of tumorigenesis, remains p…
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Nanoprodrug targeting tumor-associated intracellular bacteria enhances colorectal cancer immunotherapy.
The tumor-associated intracellular microbiota influences cancer progression by fostering an immunosuppressive tumor microenvironment. Targeting pro-tumor intracellular bacteria may represent a promising strategy for cancer immunotherapy. He…
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Engineered Self-Activatable Polymeric Nanozymes Precisely Eradicate Tumor-Associated Intramacrophage Bacteria to Potentiate Immunotherapy Based on Cluster of Differentiation 47 Blockade.
Immunotherapy for colorectal cancer (CRC) remains clinically limited by a profoundly immunosuppressive tumor microenvironment. (), which selectively colonizes CRC tumors, drives this immunosuppression by persisting within macrophages and d…
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SENP3 drives colorectal cancer progression by enhancing GDF15 expression.
[BACKGROUND] SUMO-specific peptidase 3 (SENP3), as a de-SUMOylating enzyme, renders the process of protein SUMOylation reversible. It has been demonstrated to play either promoting or inhibitory roles in several cancers. However, research o…
- Real-World Study of anti-PD-1 Combined with Regorafenib and Raltitrexed as Third-Line Therapy in Colorectal Cancer.
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A boronate affinity-enhanced and PEGylated cell-imprinted platform for efficient capture of circulating colorectal cancer cells.
[BACKGROUND] Colorectal cancer (CRC) is a leading cause of cancer mortality worldwide, with metastasis contributing significantly to poor prognosis. The detection of circulating tumor cells (CTCs) in blood, a form of liquid biopsy, offers a…
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Huang-qin decoction increases the sensitivity of EGFR-TKIs to NSCLC cells by regulating stat3/GPX4 to induce redox ratio and ROS to inhibit CSCs.
[OBJECTIVES] Our aim is to explore the combined effects and the potential mechanism between Huang-qin decoction (HQD) and epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) in non-small cell lung cancer (NSCLC) cells a…
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Zinc finger TRAF-type containing 1 can promote the progression and metastasis of lung adenocarcinoma.
[OBJECTIVE] Lung adenocarcinoma is a type of lung cancer that falls under the category of non-small cell carcinoma. Given its high incidence, it has attracted considerable attention. Zinc finger TRAF-type containing 1 (ZFTRAF1) was found in…
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Efficacy and safety of savolitinib in Chinese patients with locally advanced or metastatic exon 14-mutated non-small cell lung cancer: final results of a confirmatory Phase 3b study.
[BACKGROUND] Savolitinib, a potent MET inhibitor, showed promising efficacy and tolerable safety in a Phase 3b confirmatory trial for the treatment of Chinese patients with non-small cell lung cancer (NSCLC) harbouring MET exon 14 (ex14)-sk…
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A Natural LDHA Allosteric Inhibitor Geraniin Suppresses Triple-Negative Breast Cancer Cell Growth.
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with no target, and chemotherapy remains the only treatment in the clinic. Lactate dehydrogenase A (LDHA), a critical enzyme in glycolysis, was reported to…
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Sequential Tumor Microenvironment Reprogramming by Nanoplatform Potentiates Sonodynamic-Chemodynamic Therapy and Immune Checkpoint Blockade in Breast Cancer.
The complex tumor microenvironment (TME) remains a major barrier to effective breast cancer therapy. A modular nanoplatform capable of sequentially reprogramming the TME through cascade actions and responsive therapeutic functions is develo…
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Efficacy and safety of radiotherapy as a bridging strategy to CD19-targeted CAR-T therapy: systematic review and meta-analysis.
Radiotherapy (RT) is increasingly used as bridging therapy before CD19-targeted CAR-T infusion in large B-cell lymphoma, but its clinical role remains uncertain. We conducted a systematic review and meta-analysis of 16 studies involving 488…
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Tumor-Promoting Gut Microbes in Colorectal Cancer: Mechanisms and Translational Perspectives.
Colorectal cancer (CRC) represents a predominant global malignancy, characterized by increasing incidence and mortality rates. Recent investigations have underscored the gut microbiota as a pivotal element in the pathogenesis and progressio…