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Amide proton transfer-weighted MRI distinguishes hepatocellular carcinoma from mass-forming intrahepatic cholangiocarcinoma.

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Magnetic resonance imaging 2025 Vol.123() p. 110491
Retraction 확인
출처
PubMed DOI

PICO 자동 추출 (휴리스틱, conf 3/4)

유사 논문
P · Population 대상 환자/모집단
76 Patients with histo-pathologically confirmed HCC or MF-ICC underwent dynamic contrast enhanced(DCE) MRI,APTw and DWI.
I · Intervention 중재 / 시술
dynamic contrast enhanced(DCE) MRI,APTw and DWI
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
The optimal APTw threshold for differentiating HCC from MF-ICC was 0.04 %, with a sensitivity of 92 % and a specificity of 78 %. [CONCLUSION] APTw MRI demonstrated superior discrimination to DWI and comparable diagnostic efficacy to DCE-MRI in differentiating HCC from MF-ICC.

Huang J, Shen D, Sun J, Shi J, Dou W, Prince M

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓
📝 환자 설명용 한 줄

[OBJECTIVE] To investigate the potential of amide proton transfer-weighted (APTw) MRI in differentiating hepatocellular carcinoma (HCC) from mass-forming intrahepatic cholangiocarcinoma (MF-ICC).

🔬 핵심 임상 통계 (초록에서 자동 추출 — 원문 검증 권장)
  • 표본수 (n) 53
  • p-value P < 0.001
  • Sensitivity 92 %
  • Specificity 78 %

이 논문을 인용하기

↓ .bib ↓ .ris
APA Huang J, Shen D, et al. (2025). Amide proton transfer-weighted MRI distinguishes hepatocellular carcinoma from mass-forming intrahepatic cholangiocarcinoma.. Magnetic resonance imaging, 123, 110491. https://doi.org/10.1016/j.mri.2025.110491
MLA Huang J, et al.. "Amide proton transfer-weighted MRI distinguishes hepatocellular carcinoma from mass-forming intrahepatic cholangiocarcinoma.." Magnetic resonance imaging, vol. 123, 2025, pp. 110491.
PMID 40789564 ↗
DOI 10.1016/j.mri.2025.110491

Abstract

[OBJECTIVE] To investigate the potential of amide proton transfer-weighted (APTw) MRI in differentiating hepatocellular carcinoma (HCC) from mass-forming intrahepatic cholangiocarcinoma (MF-ICC).

[METHODS] 76 Patients with histo-pathologically confirmed HCC or MF-ICC underwent dynamic contrast enhanced(DCE) MRI,APTw and DWI. Mean APTw and apparent diffusion coefficient (ADC) of liver tumors were measured independently by two radiologists. Five-point scale were scored with DCE images. Receiver operating characteristic (ROC) curve analysis was used to assess the diagnostic performance of APTw, ADC,DCE in differentiating HCC from MF-ICC.

[RESULTS] The HCC group (n = 53) exhibited higher APTw values compared to the MF-ICC group (n = 23)(1.37 ± 0.99 % vs. -0.31 ± 0.79 %, P < 0.001). The ADC values of HCC were lower than those of MF-ICC (0.87 ± 0.14 mm/s vs. 1.02 ± 0.20 mm/s, P < 0.001). In differentiating HCC from MF-ICC, APTw demonstrated significantly higher diagnostic accuracy than ADC (AUC: 0.90 vs. 0.72; P < 0.001) and comparable efficacy to DCE-MRI (AUC: 0.90 vs. 0.92; P > 0.05). The optimal APTw threshold for differentiating HCC from MF-ICC was 0.04 %, with a sensitivity of 92 % and a specificity of 78 %.

[CONCLUSION] APTw MRI demonstrated superior discrimination to DWI and comparable diagnostic efficacy to DCE-MRI in differentiating HCC from MF-ICC.

🏷️ 키워드 / MeSH 📖 같은 키워드 OA만

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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반