Caseazins R-Y, cytotoxic podocarpane diterpenoids from Casearia kurzii.
1/5 보강
In the present study, eight undescribed compounds, namely caseazins R-Y (1-8) were isolated from the twigs and leaves of Casearia kurzii (Flacourtiaceae).
APA
Wu XW, Wei Q, et al. (2026). Caseazins R-Y, cytotoxic podocarpane diterpenoids from Casearia kurzii.. Phytochemistry, 241, 114675. https://doi.org/10.1016/j.phytochem.2025.114675
MLA
Wu XW, et al.. "Caseazins R-Y, cytotoxic podocarpane diterpenoids from Casearia kurzii.." Phytochemistry, vol. 241, 2026, pp. 114675.
PMID
40930408 ↗
Abstract 한글 요약
In the present study, eight undescribed compounds, namely caseazins R-Y (1-8) were isolated from the twigs and leaves of Casearia kurzii (Flacourtiaceae). Their structures were elucidated by extensive spectroscopic analysis, nuclear magnetic resonance methods, X-ray diffraction analysis, and ECD calculations. Compound 1 was characterized as a rare 2,3-seco podocarpane carbon skeleton. While compound 8 was a highly oxygenated podocarpane diterpenoid dimer with an oxygen bridge between C-2 and C-11'. In bioassay, the diterpenoid dimer 8 showed potential cytotoxic activity against colorectal cancer cells (SW-620) with IC value of 7.29 ± 0.10 μM. Besides, compound 8 exhibited moderate inhibitory activity against colorectal cancer target PI3Kα.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Diterpenes
- Humans
- Antineoplastic Agents
- Phytogenic
- Drug Screening Assays
- Antitumor
- Molecular Structure
- Casearia
- Cell Line
- Tumor
- Cell Proliferation
- Structure-Activity Relationship
- Plant Leaves
- Dose-Response Relationship
- Drug
- Molecular Conformation
- Casearia kurzii
- Cytotoxic activity
- Diterpenoid
- Flacourtiaceae
- Molecular docking
- Podocarpane
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