Src promotes tumor cell invasion by hijacking the translation machineries.
2/5 보강
TL;DR
It is determined that Src regulates mRNA translation and controls the expression of eIF3 subunits, including eIF3h, eIF3e, and eIF3d, crucial for invadosome formation and ECM degradation.
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: hepatocellular carcinoma (HCC), promoting ECM degradation and tumor invasiveness of HCC cells
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Moreover, overexpression of Src and eIF3h/e/d correlates with poor prognosis in patients with hepatocellular carcinoma (HCC), promoting ECM degradation and tumor invasiveness of HCC cells. This study identifies Src as a major regulator of translation initiation, modulating invadosome formation, ECM degradation, and tumor cell invasion.
OpenAlex 토픽 ·
Cell Adhesion Molecules Research
RNA and protein synthesis mechanisms
Wnt/β-catenin signaling in development and cancer
It is determined that Src regulates mRNA translation and controls the expression of eIF3 subunits, including eIF3h, eIF3e, and eIF3d, crucial for invadosome formation and ECM degradation.
APA
B. Bonnard, Anouk Chatefau, et al. (2026). Src promotes tumor cell invasion by hijacking the translation machineries.. Cell reports, 45(3), 116989. https://doi.org/10.1016/j.celrep.2026.116989
MLA
B. Bonnard, et al.. "Src promotes tumor cell invasion by hijacking the translation machineries.." Cell reports, vol. 45, no. 3, 2026, pp. 116989.
PMID
41734063 ↗
Abstract 한글 요약
The Src oncogene controls cancer cell invasiveness by promoting invadosome formation and extracellular matrix (ECM) degradation. Invadosomes are translational hotspots enriched in the eukaryotic translation initiation factor 3 (eIF3) complex that is mandatory for their maintenance. Here, we determined that Src regulates mRNA translation and controls the expression of eIF3 subunits, including eIF3h, eIF3e, and eIF3d. These subunits are crucial for invadosome formation and ECM degradation. Src also modulates both canonical eIF4E-dependent translation via the activation of the phosphoinositide-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway and the non-canonical translation mechanism through eIF3d overexpression, both of which are necessary for invadosome function. Moreover, overexpression of Src and eIF3h/e/d correlates with poor prognosis in patients with hepatocellular carcinoma (HCC), promoting ECM degradation and tumor invasiveness of HCC cells. This study identifies Src as a major regulator of translation initiation, modulating invadosome formation, ECM degradation, and tumor cell invasion.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Neoplasm Invasiveness
- Protein Biosynthesis
- src-Family Kinases
- Eukaryotic Initiation Factor-3
- Cell Line
- Tumor
- Extracellular Matrix
- Liver Neoplasms
- Podosomes
- Carcinoma
- Hepatocellular
- TOR Serine-Threonine Kinases
- Phosphatidylinositol 3-Kinases
- Animals
- Signal Transduction
- Proto-Oncogene Proteins c-akt
- Cell Movement
- CP: cancer
- CP: molecular biology
- Src
- cancer
- eIF3
- invadosomes
… 외 2개
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