Plasticity as Resistance: KRAS Inhibition Reveals WNT Adaptation in Metastatic Colorectal Cancer.
1/5 보강
Centonze and colleagues demonstrate that KRASG12D inhibition in metastatic colorectal cancer triggers rapid transcriptional reprogramming from a metastasis-associated EMP1+ state to a WNT-driven LGR5+
APA
Eng G, Yilmaz OH (2026). Plasticity as Resistance: KRAS Inhibition Reveals WNT Adaptation in Metastatic Colorectal Cancer.. Cancer discovery, 16(2), 201-203. https://doi.org/10.1158/2159-8290.CD-25-2147
MLA
Eng G, et al.. "Plasticity as Resistance: KRAS Inhibition Reveals WNT Adaptation in Metastatic Colorectal Cancer.." Cancer discovery, vol. 16, no. 2, 2026, pp. 201-203.
PMID
41645712 ↗
Abstract 한글 요약
Centonze and colleagues demonstrate that KRASG12D inhibition in metastatic colorectal cancer triggers rapid transcriptional reprogramming from a metastasis-associated EMP1+ state to a WNT-driven LGR5+ stem cell-like state, a plastic adaptation captured through real-time live cell imaging, revealing cell state conversion as a mechanism of therapeutic resistance that can be exploited through combinatorial targeting. See related article by Centonze et al., p. 320.
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