Prehabilitation combined with early oral nutrition reduces postoperative complications and hospital stay in older patients undergoing colorectal cancer surgery: A retrospective propensity score-matched analysis.
[BACKGROUND] Prehabilitation and early oral nutrition have been shown to improve postoperative outcomes in colorectal cancer (CRC).
- 표본수 (n) 73
- p-value P = 0.038
- p-value P = 0.005
- 연구 설계 cohort study
APA
Shimamura Y, Honma S, et al. (2026). Prehabilitation combined with early oral nutrition reduces postoperative complications and hospital stay in older patients undergoing colorectal cancer surgery: A retrospective propensity score-matched analysis.. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition. https://doi.org/10.1002/ncp.70120
MLA
Shimamura Y, et al.. "Prehabilitation combined with early oral nutrition reduces postoperative complications and hospital stay in older patients undergoing colorectal cancer surgery: A retrospective propensity score-matched analysis.." Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2026.
PMID
41902576
Abstract
[BACKGROUND] Prehabilitation and early oral nutrition have been shown to improve postoperative outcomes in colorectal cancer (CRC). However, their combined effects remain unexamined. This study evaluates the effects of a perioperative support (POS) program, integrating prehabilitation and early oral nutrition, on postoperative outcomes in older patients with CRC using propensity score matching (PSM).
[METHODS] We conducted a retrospective cohort study comparing patients with stage I-III CRC aged ≥75 years undergoing curative surgery before (April 2019 to March 2021; control group) and after (April 2021 to March 2023; POS group) POS program implementation. Patients were matched for baseline characteristics and perioperative variables using 1:1 nearest-neighbor PSM. The primary outcome was the 30-day postoperative complication rate according to the Clavien-Dindo classification (Grade ≥II). The secondary outcome was length of hospital stay (LOS).
[RESULTS] A total of 155 patients were included (POS group: n = 73; control group: n = 82). After PSM, each variable was well balanced between the two groups, with 48 pairs successfully matched. The rate of postoperative complications was significantly lower in the POS group than in the control group (16.7% vs 37.5%, P = 0.038), and the median LOS was significantly shorter in the POS group (8 vs 11 days, P = 0.005) after PSM.
[CONCLUSION] The POS program may reduce postoperative complications and shorten LOS in older patients with CRC.
[METHODS] We conducted a retrospective cohort study comparing patients with stage I-III CRC aged ≥75 years undergoing curative surgery before (April 2019 to March 2021; control group) and after (April 2021 to March 2023; POS group) POS program implementation. Patients were matched for baseline characteristics and perioperative variables using 1:1 nearest-neighbor PSM. The primary outcome was the 30-day postoperative complication rate according to the Clavien-Dindo classification (Grade ≥II). The secondary outcome was length of hospital stay (LOS).
[RESULTS] A total of 155 patients were included (POS group: n = 73; control group: n = 82). After PSM, each variable was well balanced between the two groups, with 48 pairs successfully matched. The rate of postoperative complications was significantly lower in the POS group than in the control group (16.7% vs 37.5%, P = 0.038), and the median LOS was significantly shorter in the POS group (8 vs 11 days, P = 0.005) after PSM.
[CONCLUSION] The POS program may reduce postoperative complications and shorten LOS in older patients with CRC.