Prognostic utility of cachexia in lung cancer: A multicenter cohort analysis.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: AWGC-defined cachexia had significantly poorer survival (55
I · Intervention 중재 / 시술
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C · Comparison 대조 / 비교
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O · Outcome 결과 / 결론
30.0 %, p < 0.001). [CONCLUSIONS] AWGC-defined cachexia is an independent risk factor for both long-term prognosis and 90-day mortality in lung cancer patients.
[BACKGROUND] The clinical significance of the Asian Working Group on Cachexia (AWGC) criteria, as a novel diagnostic standard for cachexia, remains underexplored.
- p-value p < 0.001
- 95% CI 1.306-1.580
- OR 3.060
- HR 1.436
APA
Wei L, Ruan G, et al. (2025). Prognostic utility of cachexia in lung cancer: A multicenter cohort analysis.. Clinical nutrition ESPEN, 70, 463-470. https://doi.org/10.1016/j.clnesp.2025.10.017
MLA
Wei L, et al.. "Prognostic utility of cachexia in lung cancer: A multicenter cohort analysis.." Clinical nutrition ESPEN, vol. 70, 2025, pp. 463-470.
PMID
41173213 ↗
Abstract 한글 요약
[BACKGROUND] The clinical significance of the Asian Working Group on Cachexia (AWGC) criteria, as a novel diagnostic standard for cachexia, remains underexplored. This study aims to investigate the prognostic value of the AWGC criteria and to propose a scoring system for stratifying the severity of cachexia in lung cancer patients.
[METHODS] Survival curves were generated using Kaplan-Meier analysis with log-rank tests. Cox proportional hazards models were employed for survival analysis, providing hazard ratios (HRs) and corresponding 95 % confidence intervals (CIs). Logistic regression analysis was utilized to assess the independent association between cachexia and 90-day mortality, presenting the results as odds ratios (ORs) with 95 % CIs.
[RESULTS] This study enrolled a total of 3,424 lung cancer patients, comprising 86.6 % with non-small cell lung cancer (NSCLC) and 13.4 % with small cell lung cancer (SCLC). Patients with AWGC-defined cachexia had significantly poorer survival (55.8 % vs. 39.3 %, p < 0.001). Cachectic patients exhibited considerably worse survival rates in both SCLC (42.9 % vs. 25.4 %, p < 0.001) and NSCLC (57.8 % vs. 41.4 %, p < 0.001). Cox regression analysis indicated that AWGC-defined cachexia is an independent risk factor for survival in lung cancer patients (HR: 1.436, 95 % CI: 1.306-1.580, p < 0.001). Moreover, AWGC-defined cachexia was significantly associated with poor prognosis in both SCLC (HR: 1.307, 95 % CI: 1.007-1.698, p = 0.044) and NSCLC (HR: 1.377, 95 % CI: 1.234-1.538, p < 0.001) patients. AWGC-defined cachexia was also found to be an independent risk factor for 90-day mortality in lung cancer patients (OR = 3.060, 95 % CI: 2.254-4.155, p < 0.001). We developed a severity grading system for categorizing cachexia into Mild, Moderate, and Severe. Survival rates gradually decreased as the severity grading score increased (63.2 % vs. 49.1 % vs. 37.0 % vs. 30.0 %, p < 0.001).
[CONCLUSIONS] AWGC-defined cachexia is an independent risk factor for both long-term prognosis and 90-day mortality in lung cancer patients.
[METHODS] Survival curves were generated using Kaplan-Meier analysis with log-rank tests. Cox proportional hazards models were employed for survival analysis, providing hazard ratios (HRs) and corresponding 95 % confidence intervals (CIs). Logistic regression analysis was utilized to assess the independent association between cachexia and 90-day mortality, presenting the results as odds ratios (ORs) with 95 % CIs.
[RESULTS] This study enrolled a total of 3,424 lung cancer patients, comprising 86.6 % with non-small cell lung cancer (NSCLC) and 13.4 % with small cell lung cancer (SCLC). Patients with AWGC-defined cachexia had significantly poorer survival (55.8 % vs. 39.3 %, p < 0.001). Cachectic patients exhibited considerably worse survival rates in both SCLC (42.9 % vs. 25.4 %, p < 0.001) and NSCLC (57.8 % vs. 41.4 %, p < 0.001). Cox regression analysis indicated that AWGC-defined cachexia is an independent risk factor for survival in lung cancer patients (HR: 1.436, 95 % CI: 1.306-1.580, p < 0.001). Moreover, AWGC-defined cachexia was significantly associated with poor prognosis in both SCLC (HR: 1.307, 95 % CI: 1.007-1.698, p = 0.044) and NSCLC (HR: 1.377, 95 % CI: 1.234-1.538, p < 0.001) patients. AWGC-defined cachexia was also found to be an independent risk factor for 90-day mortality in lung cancer patients (OR = 3.060, 95 % CI: 2.254-4.155, p < 0.001). We developed a severity grading system for categorizing cachexia into Mild, Moderate, and Severe. Survival rates gradually decreased as the severity grading score increased (63.2 % vs. 49.1 % vs. 37.0 % vs. 30.0 %, p < 0.001).
[CONCLUSIONS] AWGC-defined cachexia is an independent risk factor for both long-term prognosis and 90-day mortality in lung cancer patients.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Aged
- Female
- Humans
- Male
- Middle Aged
- Cachexia
- Carcinoma
- Non-Small-Cell Lung
- Cohort Studies
- Kaplan-Meier Estimate
- Lung Neoplasms
- Prognosis
- Proportional Hazards Models
- Risk Factors
- Severity of Illness Index
- Small Cell Lung Carcinoma
- Asian working group for cachexia criteria
- Cancer cachexia
- Lung cancer
- Prognostic
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