Albumin-myosteatosis gauge as predictor of survival time in patients with lung cancer treated with immune checkpoint inhibitors.
[BACKGROUND] &Aims: To explore the value of pretreatment myosteatosis and albumin-myosteatosis gauge (AMG) in predicting overall survival (OS) in patients with lung cancer treated with immune checkpoi
- p-value p = 0.003
- p-value p < 0.05
- 95% CI 0.77-2.76
- HR 1.46
APA
Wei L, Tian M, et al. (2026). Albumin-myosteatosis gauge as predictor of survival time in patients with lung cancer treated with immune checkpoint inhibitors.. Clinical nutrition ESPEN, 103288. https://doi.org/10.1016/j.clnesp.2026.103288
MLA
Wei L, et al.. "Albumin-myosteatosis gauge as predictor of survival time in patients with lung cancer treated with immune checkpoint inhibitors.." Clinical nutrition ESPEN, 2026, pp. 103288.
PMID
41974370
Abstract
[BACKGROUND] &Aims: To explore the value of pretreatment myosteatosis and albumin-myosteatosis gauge (AMG) in predicting overall survival (OS) in patients with lung cancer treated with immune checkpoint inhibitors (ICIs).
[METHODS] This single-center, retrospective study included a total of 119 patients with lung cancer. Myosteatosis was accessed on pretreatment CT at L3 level by mean skeletal muscle density (SMD). AMG was calculated as SMD * serum albumin. The time-dependent receiver operating characteristic curve was used to determine the optimal AMG score cut-off value. The predictive value of myosteatosis and AMG on overall survival were evaluated by the Kaplan-Meier method and Cox proportional hazard models. A nomogram was created based on AMG to predict OS.
[RESULTS] Patients with low AMG had shorter OS compared with patients with high AMG. (3-year survival rate: low AMG, 20.8% [95%CI: 8.4%-51.9%] versus high AMG, 68.2% [95%CI: 52.4%-88.7%]) No significate difference was observed in patients with and without myosteatosis. (HR= 1.46, 95%CI 0.77-2.76, P=0.246) In the multivariable analysis, AMG remained a significant predictor of OS. (HR = 3.29, 95% CI 1.51-7.16, p = 0.003) The prediction model for OS based on the AMG was also created with C-index 0.78. A statistically significant but weak positive correlation was observed between myosteatosis and sarcopenia (Phi coefficient = 0.24, p < 0.05).
[CONCLUSION] AMG was a significant prognostic factor of OS in patients with lung cancer treated with ICIs. A weak correlation between mysteotosis and sarcopenia was observed in patients with lung cancer.
[METHODS] This single-center, retrospective study included a total of 119 patients with lung cancer. Myosteatosis was accessed on pretreatment CT at L3 level by mean skeletal muscle density (SMD). AMG was calculated as SMD * serum albumin. The time-dependent receiver operating characteristic curve was used to determine the optimal AMG score cut-off value. The predictive value of myosteatosis and AMG on overall survival were evaluated by the Kaplan-Meier method and Cox proportional hazard models. A nomogram was created based on AMG to predict OS.
[RESULTS] Patients with low AMG had shorter OS compared with patients with high AMG. (3-year survival rate: low AMG, 20.8% [95%CI: 8.4%-51.9%] versus high AMG, 68.2% [95%CI: 52.4%-88.7%]) No significate difference was observed in patients with and without myosteatosis. (HR= 1.46, 95%CI 0.77-2.76, P=0.246) In the multivariable analysis, AMG remained a significant predictor of OS. (HR = 3.29, 95% CI 1.51-7.16, p = 0.003) The prediction model for OS based on the AMG was also created with C-index 0.78. A statistically significant but weak positive correlation was observed between myosteatosis and sarcopenia (Phi coefficient = 0.24, p < 0.05).
[CONCLUSION] AMG was a significant prognostic factor of OS in patients with lung cancer treated with ICIs. A weak correlation between mysteotosis and sarcopenia was observed in patients with lung cancer.
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