논문 목록
6건-
tRNA mG methyltransferase complex THUMPD3-TRMT112 promotes pancreatic cancer progression and autophagy via modulating TFEB translation.
Pancreatic cancer exhibits a heightened level of autophagy, which supports the survival of cancer cells within the malignant microenvironment. The THUMP domain-containing protein 3 (THUMPD3)/ tRNA Methyltransferase Activator Subunit 11-2 (T…
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Securinine, a novel alkaloid, regulates cell cycle and EMT in gastric cancer by inducing iron-dependent cell death.
[BACKGROUND] Gastric cancer remains one of the most prevalent and lethal cancers worldwide, with its insidious onset hindering early diagnosis and effective treatment. Despite advances, the overall survival rate for gastric cancer remains l…
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Bisdemethoxycurcumin suppresses liver fibrosis-associated hepatocellular carcinoma via inhibiting CXCL12-induced macrophage polarization.
Chronic, unresolved inflammation correlates with persistent hepatic injury and fibrosis, ultimately progressing to hepatocellular carcinoma (HCC). Bisdemethoxycurcumin (BDMC) demonstrates therapeutic potential against HCC, yet its mechanism…
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Prognostic Significance of the Controlling Nutritional Status Score in Non-Small Cell Lung Cancer Patients Undergoing Neoadjuvant Therapy: Development of a Predictive Nomogram.
[OBJECTIVES] To evaluate whether the Controlling Nutritional Status (CONUT) score measured before the start of neoadjuvant therapy is associated with overall survival (OS) and disease-free survival (DFS) after lung resection for non-small-c…
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BAP1 regulates HSF1 activity and cancer immunity in pancreatic cancer.
[BACKGROUND] The vast majority of pancreatic cancers have been shown to be insensitive to single-agent immunotherapy. Exploring the mechanisms of immune resistance and implementing combination therapeutic strategies are crucial for PDAC pat…
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The role of MAPK pathway in gastric cancer: unveiling molecular crosstalk and therapeutic prospects.
Gastric cancer remains a significant health burden globally, especially prevalent in Asian and European regions. Despite a notable decline in incidence in the United States and Western Europe over recent decades, the disease's persistence u…