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Selective Inhibition of Na1.8 with VX-548 for Acute Pain.
[BACKGROUND] The Na1.8 voltage-gated sodium channel, expressed in peripheral nociceptive neurons, plays a role in transmitting nociceptive signals. The effect of VX-548, an oral, highly selective inhibitor of Na1.8, on control of acute pain…
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Guideline No. 423: Female Genital Cosmetic Surgery and Procedures.
[OBJECTIVE] To provide Canadian surgeons and other providers who offer female genital cosmetic surgery (FGCS) and procedures, and their referring practitioners, with evidence-based direction in response to increasing requests for, and avail…