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Selective Inhibition of Na1.8 with VX-548 for Acute Pain.
[BACKGROUND] The Na1.8 voltage-gated sodium channel, expressed in peripheral nociceptive neurons, plays a role in transmitting nociceptive signals. The effect of VX-548, an oral, highly selective inhibitor of Na1.8, on control of acute pain…
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Using Ultrasound to Evaluate Nasal Septal Cartilage.
Having a noninvasive tool that quantifies the amount of remaining septal cartilage in the setting of prior septoplasty would be useful for surgical planning and patient counseling. The objective of this pilot study is to determine if endoc…
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High rates of fatigue and sleep disturbances in dystonia.
[BACKGROUND] Nonmotor symptoms in dystonia are increasingly recognized to impair the quality of life. The primary objective of this study was to determine the prevalence of fatigue and sleep disturbances in dystonia and to ascertain their i…
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Necrotizing perineal infections.
Necrotizing perineal infections ("Fournier's gangrene") are polymicrobial, gas producing, and rapidly progressive. Rapid resuscitation and adequate debridement are essential in the early treatment of these infections. Repeat debridements un…