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Taraxacum mongolicum Hand.-Mazz. extract disrupts the interaction between triple-negative breast cancer cells and tumor-associated macrophages by inhibiting RAC2/NF-κB p65/p38 MAPK pathway.
[ETHNOPHARMACOLOGICAL RELEVANCE] Taraxacum mongolicum Hand.-Mazz., generally known as dandelion, is a herb renowned for its pharmacological properties, including detoxifying and anti-inflammatory effects. Historically, this herb has been ex…
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SILAC proteomics based on 3D cell spheroids unveils the role of RAC2 in regulating the crosstalk between triple-negative breast cancer cells and tumor-associated macrophages.
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and is characterized by a high infiltration of tumor-associated macrophages (TAMs). TAMs contribute significantly to tumor progression by intricately inte…