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Prediction formulas for individual opioid analgesic requirements based on genetic polymorphism analyses.
[BACKGROUND] The analgesic efficacy of opioids is well known to vary widely among individuals, and various factors related to individual differences in opioid sensitivity have been identified. However, a prediction model to calculate approp…
- Successful perioperative management of a patient with primary systemic carnitine deficiency: a case report.
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Association between OPRM1 gene polymorphisms and fentanyl sensitivity in patients undergoing painful cosmetic surgery.
Individual differences in sensitivity to fentanyl, a widely used opioid analgesic, can hamper effective pain treatment. Still controversial is whether the single nucleotide polymorphisms (SNPs) of the human OPRM1 gene encoding the mu-opioid…
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[Reconstructive surgery for head and neck cancers under multiple facility cooperation system].
The problems with the system for reconstructive surgery for head and neck cancers in our department where plastic surgeons are regularly invited from distant facilities were discussed. Especially, the importance of preoperative discussion b…