논문 목록
7건-
Mutant KRAS Suppresses DNA Sensing by Remodeling Membrane Tension to Clear Extracellular Tumor DNA.
Extracellular tumor-derived DNA (tDNA) has emerged as an important biomarker for cancer diagnosis and monitoring. A better understanding of the mechanisms controlling the abundance of tDNA could help improve biomarker and treatment strategi…
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ISGylation prevents autophagic degradation of STING and promotes antitumor immunity in lung cancer.
The STING pathway plays a central role in immune activation; however, STING protein levels decline during the progression of various cancers, including lung cancer, thereby limiting the efficacy of immunotherapies. Our study uncovers a prev…
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Stress granule regulator-associated genes predict drug sensitivity, immune infiltration, and prognosis in patients with gastric cancer: Insights from bioinformatic and experimental approaches.
[OBJECTIVE] Stress granule (SG) regulators affect tumor progression in patients with gastric cancer (GC). This study aimed to explore the effects of SG-related genes on the prognosis, immune characteristics, and drug sensitivity of patients…
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Effects of Neoadjuvant Chemotherapy on Early Postoperative Anxiety and Depression in Patients With Gastric Cancer: An Observational Study.
[AIM] Neoadjuvant chemotherapy (NACT) improves surgical outcomes in gastric cancer, yet its effect on early postoperative mental health remains unclear. This study aims to investigate the association between NACT and postoperative anxiety a…
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Association of Recurrence with a Tumor-informed Personalized ctDNA Detection Approach in Resectable Colorectal Cancer: Results of a Prospective Observational Study.
[OBJECTIVE] Primary objective was to evaluate the association between post-surgical MRD detected by a tumor-informed personalized panel (brPROPHET) and CRC recurrence, Secondary objectives were to determine the optimal timepoint for MRD ass…
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Pteris wallichiana bioactives induce ferroptosis via the SLC7A11-GSH-GPX4 axis to directly suppress colorectal cancer.
[BACKGROUND] Colorectal cancer (CRC) is the second most lethal form of cancer and the third most prevalent malignancy worldwide. Surgery, chemotherapy, and targeted therapy have been extensively utilized in the treatment of CRC. However, so…
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Clinical outcomes after microsurgical resection of giant lateral ventricular meningiomas.
Giant lateral ventricular meningiomas (LVMs), with the largest diameter of at least 5 cm, form a distinct subset. The incidence of giant LVMs is considered to be relatively low. Here, we evaluated clinical characteristics, and clinical outc…