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Challenging Interchangeability: Dynamic Dose-Response Modelling of Botulinum Toxin A Products.
[INTRODUCTION] Botulinum Neurotoxin type A (BoNT-A) formulations are used worldwide for both aesthetic and therapeutic indications, yet dose conversion between products remains based on empirical ratios that ignore pharmacodynamic variabili…
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Botulinum Toxin Accessory Proteins: Are They Just an Accessory?
[BACKGROUND] Botulinum neurotoxins produced by Clostridium botulinum consist of a complex of a core neurotoxin protein and one or more nontoxin accessory proteins. The accessory proteins are generally thought to protect the neurotoxin from …
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Post Hoc Analysis Comparing the Safety and Efficacy of PrabotulinumtoxinA in Millennials and Nonmillennials With Moderate to Severe Glabellar Lines.
[BACKGROUND] Millennials accept and invest in aesthetic procedures more than older generations. [OBJECTIVE] To compare efficacy outcomes between millennial and nonmillennial patients after treatment of glabellar lines with prabotulinumtoxi…