Evaluating the prognostic value of Wnt signaling pathways in non-small cell lung cancer patients.
1/5 보강
[PURPOSE] The Wnt/β-catenin signaling pathway is frequently deregulated in various malignancies, including non-small cell lung cancer (NSCLC).
APA
Pancewicz J, Golec P, et al. (2025). Evaluating the prognostic value of Wnt signaling pathways in non-small cell lung cancer patients.. Advances in medical sciences, 71(1), 10-18. https://doi.org/10.1016/j.advms.2025.12.002
MLA
Pancewicz J, et al.. "Evaluating the prognostic value of Wnt signaling pathways in non-small cell lung cancer patients.." Advances in medical sciences, vol. 71, no. 1, 2025, pp. 10-18.
PMID
41448269
Abstract
[PURPOSE] The Wnt/β-catenin signaling pathway is frequently deregulated in various malignancies, including non-small cell lung cancer (NSCLC). This study aimed to evaluate the expression levels of genes encoding ligands that are typically associated with the non-canonical Wnt/β-catenin pathways, specifically, WNT-4, WNT-5A, WNT-7A, WNT-11, and WNT-16 in NSCLC.
[MATERIALS AND METHODS] The analysis was conducted on 80 matched pairs of tumor and adjacent non-cancerous lung tissues. Quantitative gene expression analysis was performed using real-time polymerase chain reaction (qPCR).
[RESULTS] The results revealed a consistent reduction in the expression of all investigated genes across NSCLC samples and their respective histological subtypes. Notably, elevated WNT-7A gene expression was observed between clinical early (IA) and intermediate IIA stages of NSCLC.
[CONCLUSIONS] These findings suggest that alterations in the expression of non-canonical Wnt/β-catenin pathway ligands are integral to lung carcinogenesis and may play a critical role in the development of NSCLC. The observed changes in WNT-7A expression between IA and IIA stages of NSCLC further indicate its potential involvement in tumor progression.
[MATERIALS AND METHODS] The analysis was conducted on 80 matched pairs of tumor and adjacent non-cancerous lung tissues. Quantitative gene expression analysis was performed using real-time polymerase chain reaction (qPCR).
[RESULTS] The results revealed a consistent reduction in the expression of all investigated genes across NSCLC samples and their respective histological subtypes. Notably, elevated WNT-7A gene expression was observed between clinical early (IA) and intermediate IIA stages of NSCLC.
[CONCLUSIONS] These findings suggest that alterations in the expression of non-canonical Wnt/β-catenin pathway ligands are integral to lung carcinogenesis and may play a critical role in the development of NSCLC. The observed changes in WNT-7A expression between IA and IIA stages of NSCLC further indicate its potential involvement in tumor progression.