Dose-related association between radiation exposure from computed tomography (CT) scans during trauma hospitalizations and subsequent risk of developing new-onset cancers.
코호트
1/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
2662 patients (17.
I · Intervention 중재 / 시술
a median of 6 X-rays (IQR: 3-12) and 3 CT scans (IQR:1-5) with a median DLP of 1,941 mGy*cm (IQR: 637-3,388)
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
These findings are consistent in a larger cohort of 15,352 patients after multiple imputation for missing smoking data. [CONCLUSIONS] CT-related radiation exposure during trauma hospitalizations is associated with a dose-dependent increase in the risk of subsequent cancer incidence and mortality.
[BACKGROUND] The association between radiation dose from Computed Tomography (CT) and subsequent cancer risk in adults remains poorly defined.
- 표본수 (n) 12,690
- p-value p = 0.001
- p-value p = 0.042
- 95% CI 1.01-1.16
- 추적기간 5.9 years
- 연구 설계 cohort study
APA
Yaw LK, Song S, Ho KM (2026). Dose-related association between radiation exposure from computed tomography (CT) scans during trauma hospitalizations and subsequent risk of developing new-onset cancers.. Communications medicine, 6(1), 89. https://doi.org/10.1038/s43856-025-01354-z
MLA
Yaw LK, et al.. "Dose-related association between radiation exposure from computed tomography (CT) scans during trauma hospitalizations and subsequent risk of developing new-onset cancers.." Communications medicine, vol. 6, no. 1, 2026, pp. 89.
PMID
41491845 ↗
Abstract 한글 요약
[BACKGROUND] The association between radiation dose from Computed Tomography (CT) and subsequent cancer risk in adults remains poorly defined.
[METHODS] We conducted a statewide cohort study to examine the relationship between CT-related radiation exposure - measured by dose-length-product (DLP) - and cancer outcomes among adult trauma patients in Western Australia from 2004 to 2020. Patients with a documented cancer diagnosis within five years prior to trauma were excluded.
[RESULTS] After excluding patients with missing smoking data (n = 12,690), 2662 patients (17.3%) are included in the primary analysis. The cohort is predominantly male (75.8%), with a median age of 41 years (IQR: 27-58) and a median Injury Severity Score (ISS) of 17 (IQR: 16-22). Over a median follow-up of 5.9 years (IQR: 4.0-7.9), 374 patients (14.0%) died, including 21 cancer-related deaths (0.8%), accounting for 5.6% of all deaths. During the index trauma admission, patients underwent a median of 6 X-rays (IQR: 3-12) and 3 CT scans (IQR:1-5) with a median DLP of 1,941 mGy*cm (IQR: 637-3,388). DLP and absorbed radiation dose are significantly correlated with injury severity (Pearson r = 0.209 and 0.265, respectively; both p = 0.001). Radiation exposure is significantly associated with increased risk of new-onset cancer (adjusted hazard ratio [aHR]: 1.08 per 1,000 mGy*cm increment in DLP; 95%CI: 1.01-1.16; p = 0.042) and cancer-related mortality (aHR 3.35 for those exposed to >5000 mGy*cm; 95%CI: 1.20-9.38; p = 0.021). These findings are consistent in a larger cohort of 15,352 patients after multiple imputation for missing smoking data.
[CONCLUSIONS] CT-related radiation exposure during trauma hospitalizations is associated with a dose-dependent increase in the risk of subsequent cancer incidence and mortality.
[METHODS] We conducted a statewide cohort study to examine the relationship between CT-related radiation exposure - measured by dose-length-product (DLP) - and cancer outcomes among adult trauma patients in Western Australia from 2004 to 2020. Patients with a documented cancer diagnosis within five years prior to trauma were excluded.
[RESULTS] After excluding patients with missing smoking data (n = 12,690), 2662 patients (17.3%) are included in the primary analysis. The cohort is predominantly male (75.8%), with a median age of 41 years (IQR: 27-58) and a median Injury Severity Score (ISS) of 17 (IQR: 16-22). Over a median follow-up of 5.9 years (IQR: 4.0-7.9), 374 patients (14.0%) died, including 21 cancer-related deaths (0.8%), accounting for 5.6% of all deaths. During the index trauma admission, patients underwent a median of 6 X-rays (IQR: 3-12) and 3 CT scans (IQR:1-5) with a median DLP of 1,941 mGy*cm (IQR: 637-3,388). DLP and absorbed radiation dose are significantly correlated with injury severity (Pearson r = 0.209 and 0.265, respectively; both p = 0.001). Radiation exposure is significantly associated with increased risk of new-onset cancer (adjusted hazard ratio [aHR]: 1.08 per 1,000 mGy*cm increment in DLP; 95%CI: 1.01-1.16; p = 0.042) and cancer-related mortality (aHR 3.35 for those exposed to >5000 mGy*cm; 95%CI: 1.20-9.38; p = 0.021). These findings are consistent in a larger cohort of 15,352 patients after multiple imputation for missing smoking data.
[CONCLUSIONS] CT-related radiation exposure during trauma hospitalizations is associated with a dose-dependent increase in the risk of subsequent cancer incidence and mortality.