A mitochondria-targeted green light-activatable binuclear ruthenium(II) dithiocarbamate complex for synergistic type I/II photodynamic therapy.
1/5 보강
We report the synthesis of a mitochondria-targeted binuclear ruthenium(II)-dithiocarbamate complex, [Ru(bpy)(SC(CHN)CS)Ru(bpy)](PF) (Ru1), with a significant bathochromic absorbance shift when compare
APA
Negi M, Venkatesh V (2026). A mitochondria-targeted green light-activatable binuclear ruthenium(II) dithiocarbamate complex for synergistic type I/II photodynamic therapy.. Dalton transactions (Cambridge, England : 2003), 55(1), 91-95. https://doi.org/10.1039/d5dt01997d
MLA
Negi M, et al.. "A mitochondria-targeted green light-activatable binuclear ruthenium(II) dithiocarbamate complex for synergistic type I/II photodynamic therapy.." Dalton transactions (Cambridge, England : 2003), vol. 55, no. 1, 2026, pp. 91-95.
PMID
41363552 ↗
Abstract 한글 요약
We report the synthesis of a mitochondria-targeted binuclear ruthenium(II)-dithiocarbamate complex, [Ru(bpy)(SC(CHN)CS)Ru(bpy)](PF) (Ru1), with a significant bathochromic absorbance shift when compared with the well-studied mononuclear [Ru(bpy)]Cl complex. It demonstrates excellent singlet oxygen (O) and hydroxyl radical (˙OH) generation ability under green (518 nm)/red (637 nm) light, even at ultra-low power intensity (10 mW cm). It elicits potent photocytotoxicity against human lung cancer cells (A549) and in a 3D tumor spheroid model type I/II photodynamic therapy.
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