TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: solid tumors and is associated with worsened prognosis; however, its role in tumor immunology and immune checkpoint therapy (ICT) is unknown
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
we found the Tet2-mutant myeloid cells are abundant in the tumor microenvironment and contributed to an improved response to ICT.
Clonal hematopoiesis (CH) is detectable in upwards of 20% of patients with solid tumors and is associated with worsened prognosis; however, its role in tumor immunology and immune checkpoint therapy (
APA
Herbrich S, Chaib M, et al. (2026). TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors.. Cancer cell, 44(1), 187-202.e7. https://doi.org/10.1016/j.ccell.2025.09.011
MLA
Herbrich S, et al.. "TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors.." Cancer cell, vol. 44, no. 1, 2026, pp. 187-202.e7.
PMID
41106379 ↗
Abstract 한글 요약
Clonal hematopoiesis (CH) is detectable in upwards of 20% of patients with solid tumors and is associated with worsened prognosis; however, its role in tumor immunology and immune checkpoint therapy (ICT) is unknown. Using a bone marrow chimera model of Tet2 CH in mice with solid tumors, we found the Tet2-mutant myeloid cells are abundant in the tumor microenvironment and contributed to an improved response to ICT. Mechanistically, Tet2 macrophages inside the tumor act as immunogenic antigen-presenting cells that more effectively cross-prime naive CD8 T cells in response to IFNγ. In human cohorts of 35,971 non-small cell lung cancer patients and 25,064 colorectal adenocarcinoma patients, TET2-mutant CH is associated with improved outcome specifically with ICT. This study proposes a role for Tet2 antigen presenting macrophages in shaping antitumor immunity and identifies TET2-mutant CH as a potential biomarker for improved response to ICT in patients with solid tumors.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Dioxygenases
- Animals
- Humans
- Mice
- DNA-Binding Proteins
- Clonal Hematopoiesis
- Proto-Oncogene Proteins
- Tumor Microenvironment
- Macrophages
- Immune Checkpoint Inhibitors
- Antigen Presentation
- Mutation
- Inbred C57BL
- Female
- Neoplasms
- Colorectal Neoplasms
- CD8-Positive T-Lymphocytes
- Carcinoma
- Non-Small-Cell Lung
- TET2
- antigen presentation
- clonal hematopoiesis
- cross-priming
- immune checkpoint therapy
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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