The oncomicropeptide IADMP promotes lung cancer progression by stablilized RPS3A expression.
1/5 보강
Emerging evidence suggests that long noncoding RNAs (lncRNAs) may encode functional micropeptides with diverse biological functions.
APA
Wu Y, Zhang K, et al. (2026). The oncomicropeptide IADMP promotes lung cancer progression by stablilized RPS3A expression.. Biochemical and biophysical research communications, 796, 152515. https://doi.org/10.1016/j.bbrc.2025.152515
MLA
Wu Y, et al.. "The oncomicropeptide IADMP promotes lung cancer progression by stablilized RPS3A expression.." Biochemical and biophysical research communications, vol. 796, 2026, pp. 152515.
PMID
41444079 ↗
Abstract 한글 요약
Emerging evidence suggests that long noncoding RNAs (lncRNAs) may encode functional micropeptides with diverse biological functions. Here, we identify a 79-amino acid micropeptide encoded by the human lncRNA IDH1-AS1, termed IDH1-AS1-derived micropeptide (IADMP). Functional assays demonstrate that IADMP enhances the malignant phenotypes of lung cancer cells. Mechanistically, IADMP interacts with and enhances the stability of RPS3A, a known driver of lung cancer progression. These findings reveal a previously unrecognized micropeptide axis involved in cancer biology and highlight IADMP as a potential target for therapeutic intervention.
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