Genetic evidence for POR-mediated ferroptosis in lung cancer prevention: a causal role of granulocyte modulation.
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[BACKGROUND] Cytochrome P450 oxidoreductase (POR) plays a vital role in ferroptosis within lung cancer.
APA
Qian L, Wu L, et al. (2026). Genetic evidence for POR-mediated ferroptosis in lung cancer prevention: a causal role of granulocyte modulation.. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. https://doi.org/10.1007/s12094-025-04210-7
MLA
Qian L, et al.. "Genetic evidence for POR-mediated ferroptosis in lung cancer prevention: a causal role of granulocyte modulation.." Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026.
PMID
41612005 ↗
Abstract 한글 요약
[BACKGROUND] Cytochrome P450 oxidoreductase (POR) plays a vital role in ferroptosis within lung cancer. A potential link exists between ferroptosis-related genes and immune cell activity. This research aimed to confirm whether POR influences lung cancer by modulating immune cells.
[METHODS] Genetic variants of the POR gene were identified from lung tissue expression quantitative trait loci (eQTL) data using single nucleotide polymorphisms (SNPs). A genome-wide study of 40,187 Europeans found variants linked to lung cancer. Mediation analysis on 731 immunophenotypes was done to assess their mediating effect on the POR gene-lung cancer relationship.
[RESULTS] This study identified four SNPs for further investigation. Mediation analysis suggested that three immune cell traits might mediate the effect of POR on lung cancer, with CD11c on granulocyte showing a clear mediation effect (β = - 0.01, mediation proportion = 8.18%). There was a negative correlation between CD11c on granulocyte and the POR gene (β = - 0.23), as well as a positive correlation between CD11c on granulocyte and lung cancer risk (β = 0.05).
[CONCLUSIONS] Our analysis revealed that increased expression in the POR gene was linked to a lower genetically predicted risk of lung cancer, with a significant mediation effect by the CD11c on granulocyte.
[METHODS] Genetic variants of the POR gene were identified from lung tissue expression quantitative trait loci (eQTL) data using single nucleotide polymorphisms (SNPs). A genome-wide study of 40,187 Europeans found variants linked to lung cancer. Mediation analysis on 731 immunophenotypes was done to assess their mediating effect on the POR gene-lung cancer relationship.
[RESULTS] This study identified four SNPs for further investigation. Mediation analysis suggested that three immune cell traits might mediate the effect of POR on lung cancer, with CD11c on granulocyte showing a clear mediation effect (β = - 0.01, mediation proportion = 8.18%). There was a negative correlation between CD11c on granulocyte and the POR gene (β = - 0.23), as well as a positive correlation between CD11c on granulocyte and lung cancer risk (β = 0.05).
[CONCLUSIONS] Our analysis revealed that increased expression in the POR gene was linked to a lower genetically predicted risk of lung cancer, with a significant mediation effect by the CD11c on granulocyte.
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