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Progressive Development of Pulmonary Invasive Mucinous Adenocarcinoma With SMARCA4-Deficient.

Pathology international 2026 Vol.76(2) p. e70095

Zheng H, Cui Y, Fu F, Peng F, Dai X

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SMARCA4-deficient non-small cell lung cancer is characterized by highly aggressive clinical behavior, diverse tumor subtypes, and complex histological features.

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APA Zheng H, Cui Y, et al. (2026). Progressive Development of Pulmonary Invasive Mucinous Adenocarcinoma With SMARCA4-Deficient.. Pathology international, 76(2), e70095. https://doi.org/10.1111/pin.70095
MLA Zheng H, et al.. "Progressive Development of Pulmonary Invasive Mucinous Adenocarcinoma With SMARCA4-Deficient.." Pathology international, vol. 76, no. 2, 2026, pp. e70095.
PMID 41653129
DOI 10.1111/pin.70095

Abstract

SMARCA4-deficient non-small cell lung cancer is characterized by highly aggressive clinical behavior, diverse tumor subtypes, and complex histological features. The application of the SMARCA4 immunohistochemical marker facilitates accurate identification. This study presents a rare case of SMARCA4-deficient pulmonary invasive mucinous adenocarcinoma with high-grade transformation.

MeSH Terms

Humans; DNA Helicases; Adenocarcinoma, Mucinous; Lung Neoplasms; Nuclear Proteins; Transcription Factors; Male; Biomarkers, Tumor; Middle Aged; Female; Adenocarcinoma of Lung; Carcinoma, Non-Small-Cell Lung

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