Non-intubated video-assisted thoracic surgery for operable lung cancer: a randomized controlled trial.
무작위 임상시험
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: early-stage lung cancer scheduled for video-assisted thoracoscopic surgery in a Chinese tertiary center between September 2020 and October 2021
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSIONS] NIVATS showed superiority over IVATS in maintaining intraoperative hemodynamic stability and reducing the postoperative inflammatory response. NIVATS may represent a safer and more advantageous option for patients with lung malignancies.
[BACKGROUND] The safety profile and effect on inflammation of non-intubated video-assisted thoracoscopic surgery (NIVATS) remain incompletely understood.
- p-value P = 0.03
- p-value P < 0.01
APA
Wang D, Gao T, et al. (2026). Non-intubated video-assisted thoracic surgery for operable lung cancer: a randomized controlled trial.. International journal of surgery (London, England), 112(2), 3681-3689. https://doi.org/10.1097/JS9.0000000000003986
MLA
Wang D, et al.. "Non-intubated video-assisted thoracic surgery for operable lung cancer: a randomized controlled trial.." International journal of surgery (London, England), vol. 112, no. 2, 2026, pp. 3681-3689.
PMID
41731867 ↗
Abstract 한글 요약
[BACKGROUND] The safety profile and effect on inflammation of non-intubated video-assisted thoracoscopic surgery (NIVATS) remain incompletely understood. This study aimed to evaluate the safety of NIVATS and its effect on the inflammatory state.
[METHODS] This single-center, randomized, parallel-controlled, double-blind trial enrolled patients with early-stage lung cancer scheduled for video-assisted thoracoscopic surgery in a Chinese tertiary center between September 2020 and October 2021. Patients were randomly assigned in a 1:1 ratio to undergo either NIVATS or intubated video-assisted thoracoscopic surgery (IVATS). Expression levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in blood samples, as well as expression levels of aquaporin-5 (AQP-5), surfactant protein A (SP-A), and high-mobility group box 1 (HMGB-1) in lung tissue samples, were measured. Total white blood cell (WBC) and neutrophil counts were determined using a cell counter.
[RESULTS] Intergroup baseline characteristics of 120 included patients (NIVATS group: 60; IVATS group: 60) were comparable. In the NIVATS group, the level of HMGB-1 was decreased (P = 0.03), while the levels of AQP-5 (P < 0.01) and SP-A (P < 0.01) in lung tissue were elevated. Postoperative levels of IL-6 and TNF-α did not differ significantly between the two groups (P > 0.05). Additionally, on postoperative day 1 (WBC: 9.93 ± 0.42 vs. 11.85 ± 0.51 × 109/L, P < 0.01; neutrophil: 74.37 ± 1.13% vs. 83.84 ± 0.94%, P < 0.01) and the day prior to discharge (WBC: 9.93 ± 0.42 vs. 11.85 ± 0.51 × 109/L, P < 0.01; neutrophil: 66.99 ± 1.02% vs. 76.11 ± 1.09%, P< 0.01), the NIVATS group exhibited lower WBC and neutrophil counts compared to the IVATS group.
[CONCLUSIONS] NIVATS showed superiority over IVATS in maintaining intraoperative hemodynamic stability and reducing the postoperative inflammatory response. NIVATS may represent a safer and more advantageous option for patients with lung malignancies.
[METHODS] This single-center, randomized, parallel-controlled, double-blind trial enrolled patients with early-stage lung cancer scheduled for video-assisted thoracoscopic surgery in a Chinese tertiary center between September 2020 and October 2021. Patients were randomly assigned in a 1:1 ratio to undergo either NIVATS or intubated video-assisted thoracoscopic surgery (IVATS). Expression levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in blood samples, as well as expression levels of aquaporin-5 (AQP-5), surfactant protein A (SP-A), and high-mobility group box 1 (HMGB-1) in lung tissue samples, were measured. Total white blood cell (WBC) and neutrophil counts were determined using a cell counter.
[RESULTS] Intergroup baseline characteristics of 120 included patients (NIVATS group: 60; IVATS group: 60) were comparable. In the NIVATS group, the level of HMGB-1 was decreased (P = 0.03), while the levels of AQP-5 (P < 0.01) and SP-A (P < 0.01) in lung tissue were elevated. Postoperative levels of IL-6 and TNF-α did not differ significantly between the two groups (P > 0.05). Additionally, on postoperative day 1 (WBC: 9.93 ± 0.42 vs. 11.85 ± 0.51 × 109/L, P < 0.01; neutrophil: 74.37 ± 1.13% vs. 83.84 ± 0.94%, P < 0.01) and the day prior to discharge (WBC: 9.93 ± 0.42 vs. 11.85 ± 0.51 × 109/L, P < 0.01; neutrophil: 66.99 ± 1.02% vs. 76.11 ± 1.09%, P< 0.01), the NIVATS group exhibited lower WBC and neutrophil counts compared to the IVATS group.
[CONCLUSIONS] NIVATS showed superiority over IVATS in maintaining intraoperative hemodynamic stability and reducing the postoperative inflammatory response. NIVATS may represent a safer and more advantageous option for patients with lung malignancies.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Thoracic Surgery
- Video-Assisted
- Female
- Male
- Lung Neoplasms
- Middle Aged
- Double-Blind Method
- Aged
- Interleukin-6
- Tumor Necrosis Factor-alpha
- HMGB1 Protein
- Aquaporin 5
- Pulmonary Surfactant-Associated Protein A
- inflammation
- lung cancer
- non-intubated anesthesia
- randomized controlled trial
- video-assisted thoracic surgery
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