Recurrence Patterns of Oesophageal Squamous Cell Carcinoma Differ by Tumour Location and Pathologic Stage.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
추출되지 않음
I · Intervention 중재 / 시술
curative-intent oesophagectomy between 2010 and 2020 were retrospectively analysed
C · Comparison 대조 / 비교
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O · Outcome 결과 / 결론
[CONCLUSIONS] ESCC recurrence patterns vary by tumour location, treatment modality, and pathologic stage. The lung is the most common site of distant recurrence and presents earlier than secondary lung cancer.
[OBJECTIVES] To investigate how recurrence patterns in oesophageal squamous cell carcinoma (ESCC) are influenced by primary tumour location, treatment modality, and pathologic stage, and distinguish t
- p-value P = .003
- p-value P < .001
APA
Ahn Y, Lee SM, et al. (2026). Recurrence Patterns of Oesophageal Squamous Cell Carcinoma Differ by Tumour Location and Pathologic Stage.. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 68(2). https://doi.org/10.1093/ejcts/ezag068
MLA
Ahn Y, et al.. "Recurrence Patterns of Oesophageal Squamous Cell Carcinoma Differ by Tumour Location and Pathologic Stage.." European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, vol. 68, no. 2, 2026.
PMID
41666302 ↗
Abstract 한글 요약
[OBJECTIVES] To investigate how recurrence patterns in oesophageal squamous cell carcinoma (ESCC) are influenced by primary tumour location, treatment modality, and pathologic stage, and distinguish true recurrence from frequent secondary primary malignancies.
[METHODS] A total of 953 ESCC patients (mean age, 62.6 ± 7.7 years, 883 [92.7%] male) who underwent curative-intent oesophagectomy between 2010 and 2020 were retrospectively analysed. Patients were categorized by tumour location (upper/mid vs lower), pathologic stage (0-I vs II-IV), and treatment modality (upfront surgery vs neoadjuvant chemoradiation). Recurrence patterns were classified as loco-regional, distant, or mixed. Secondary primary malignancies were also documented. Associations between recurrence patterns and post-recurrence survival (PRS) were assessed using multivariable Cox regression.
[RESULTS] Recurrence occurred in 23.4% (223/953) of patients, mostly within 2 years post-surgery (83.4%). Among early pathologic stage (0-I) patients treated with upfront surgery, upper/mid oesophageal cancers had a higher rate of loco-regional recurrence compared with lower oesophageal cancers (16.3% vs 6.7%; P = .003), particularly in the mediastinal (10.9% vs 4.8%) and supraclavicular lymph nodes (6.3% vs 1.4%). No location-related differences were observed in advanced pathologic stage (II-IV) or neoadjuvant chemoradiation groups. Distant recurrence predominated in the neoadjuvant chemotherapy group (19.6% vs 9.7%). The lung was the most frequent site of distant metastasis (7.6%-8.6%), presenting as solitary nodules (24/45). Secondary lung cancers occurred later than pulmonary recurrences (median 58.3 vs 6.9 months; P < .001). Mixed recurrence was associated with worse PRS (adjusted hazard ratio, 1.77; 95% confidence interval, 1.18-2.66; P = .006).
[CONCLUSIONS] ESCC recurrence patterns vary by tumour location, treatment modality, and pathologic stage. The lung is the most common site of distant recurrence and presents earlier than secondary lung cancer.
[METHODS] A total of 953 ESCC patients (mean age, 62.6 ± 7.7 years, 883 [92.7%] male) who underwent curative-intent oesophagectomy between 2010 and 2020 were retrospectively analysed. Patients were categorized by tumour location (upper/mid vs lower), pathologic stage (0-I vs II-IV), and treatment modality (upfront surgery vs neoadjuvant chemoradiation). Recurrence patterns were classified as loco-regional, distant, or mixed. Secondary primary malignancies were also documented. Associations between recurrence patterns and post-recurrence survival (PRS) were assessed using multivariable Cox regression.
[RESULTS] Recurrence occurred in 23.4% (223/953) of patients, mostly within 2 years post-surgery (83.4%). Among early pathologic stage (0-I) patients treated with upfront surgery, upper/mid oesophageal cancers had a higher rate of loco-regional recurrence compared with lower oesophageal cancers (16.3% vs 6.7%; P = .003), particularly in the mediastinal (10.9% vs 4.8%) and supraclavicular lymph nodes (6.3% vs 1.4%). No location-related differences were observed in advanced pathologic stage (II-IV) or neoadjuvant chemoradiation groups. Distant recurrence predominated in the neoadjuvant chemotherapy group (19.6% vs 9.7%). The lung was the most frequent site of distant metastasis (7.6%-8.6%), presenting as solitary nodules (24/45). Secondary lung cancers occurred later than pulmonary recurrences (median 58.3 vs 6.9 months; P < .001). Mixed recurrence was associated with worse PRS (adjusted hazard ratio, 1.77; 95% confidence interval, 1.18-2.66; P = .006).
[CONCLUSIONS] ESCC recurrence patterns vary by tumour location, treatment modality, and pathologic stage. The lung is the most common site of distant recurrence and presents earlier than secondary lung cancer.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
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