Roles on antiproliferation, apoptosis, necrosis and proinflammation of subsp. essential oil obtained by hydrodistillation on lung cancer cells.
1/5 보강
Lung cancer is the leading cause of death worldwide.
APA
Yumrutaş P, Korkmaz M, et al. (2026). Roles on antiproliferation, apoptosis, necrosis and proinflammation of subsp. essential oil obtained by hydrodistillation on lung cancer cells.. International journal of environmental health research, 36(3), 465-475. https://doi.org/10.1080/09603123.2025.2528939
MLA
Yumrutaş P, et al.. "Roles on antiproliferation, apoptosis, necrosis and proinflammation of subsp. essential oil obtained by hydrodistillation on lung cancer cells.." International journal of environmental health research, vol. 36, no. 3, 2026, pp. 465-475.
PMID
40632916 ↗
Abstract 한글 요약
Lung cancer is the leading cause of death worldwide. New anticancer agents are required for treatment due to the inadequacy of current treatments and side effects of the drugs used. The medicinal plants stand out as important resources because they are natural and have few or no side effects. In this study, it was aimed to determine the effects of essential oil (MFEO) on proliferation, apoptosis, necrosis and proinflammation in lung cancer cells. For this purpose, different concentrations of MFEO were applied to lung cancer cells (A549), and the cell viability and proliferation were determined by MTT assay. Percentages of early apoptotic, late apoptotic and necrotic cells were determined by Annexin-V/PI staining in Flow cytometry (FACS). In addition, proinflammatory cytokines TNF-alpha and IL8 levels were determined by ELISA method. Chemical characterization of MFEO was carried out by GC-MS and pulegon has been identified as the main component of MFEO. Consequently, it was determined that MFEO suppressed the proliferation and induced the apoptosis in A549 cells.
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