The prognostic value of the solid volume ratio of pulmonary nodules in lung adenocarcinoma.

[OBJECTIVE] To evaluate solid volume ratio (SVR) in predicting long-term postoperative outcomes in lung adenocarcinoma patients.

[METHODS] This study retrospectively analysed the clinical, pathological, and CT data of patients with lung adenocarcinoma who underwent surgical resection and were pathologically confirmed in the Department of Thoracic Surgery of our hospital from June 2014 to June 2023. Multivariate COX analysis was also conducted to identify independent factors that affect treatment effect. P < .05 was considered statistically significant.

[RESULTS] A total of 154 patients (82 males and 72 females) were included in this study. The average age was 62.11 ± 8.74 years. There were 60 patients (38.96%) who smoked, and 63 patients (40.90%) had positive pleural invasion. The 3-year disease-free survival (DFS) rate and overall survival (OS) rate after surgical resection were 87.5% and 92.0%, respectively; the 5-year DFS rate and OS rate after surgical resection were 81.6% and 89.1%, respectively. Multiple COX regression analysis showed that gender (P = .009, odds ratio [OR]: 4.197, 95% confidence interval [CI]: 1.426-12.353), and the solid volume ratio (P = .004, OR: 1.021, 95% CI: 1.007-1.036) were identified as an independent predictor of recurrence. Multivariate COX analysis showed that SVR (P = .003, OR: 1.028, 95% CI: 1.009-1.046) was identified as an independent predictor of postoperative survival in patients with lung cancer.

[CONCLUSION] In this study, compared with consolidation tumour rate (CTR), the SVR has certain value in evaluating the therapeutic efficacy of lung adenocarcinoma.

[ADVANCES IN KNOWLEDGE] SVR is an independent predictor of postoperative recurrence and survival in lung cancer, and provides new ideas for postoperative efficacy evaluation.