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Complementary Role of [ 68 Ga]Ga-DOTA-3P-TATE-RGD PET/CT in Discriminating Non-Small Cell From Small Cell Lung Cancer.

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Clinical nuclear medicine 📖 저널 OA 3.9% 2021: 0/2 OA 2022: 1/12 OA 2023: 0/8 OA 2024: 0/22 OA 2025: 3/79 OA 2026: 5/104 OA 2021~2026 2026 Vol.51(3) p. 244-246
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Xiang J, Yan Y, Zhang Z, Zhang L, Zhu Z

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[ 18 F]FDG PET/CT is widely used in the diagnosis and treatment monitoring of lung cancer, yet its ability to differentiate histologic heterogeneity remains limited.

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APA Xiang J, Yan Y, et al. (2026). Complementary Role of [ 68 Ga]Ga-DOTA-3P-TATE-RGD PET/CT in Discriminating Non-Small Cell From Small Cell Lung Cancer.. Clinical nuclear medicine, 51(3), 244-246. https://doi.org/10.1097/RLU.0000000000006258
MLA Xiang J, et al.. "Complementary Role of [ 68 Ga]Ga-DOTA-3P-TATE-RGD PET/CT in Discriminating Non-Small Cell From Small Cell Lung Cancer.." Clinical nuclear medicine, vol. 51, no. 3, 2026, pp. 244-246.
PMID 41400975 ↗

Abstract

[ 18 F]FDG PET/CT is widely used in the diagnosis and treatment monitoring of lung cancer, yet its ability to differentiate histologic heterogeneity remains limited. In this case, a 75-year-old man presented with a large pulmonary mass adjacent to a small satellite lesion. Bronchoscopic biopsy of the main lesion revealed small-cell lung cancer (SCLC). After first-line chemotherapy, the primary lesion showed partial response, while the smaller nodule remained stable. Posttreatment [ 18 F]FDG and [ 68 Ga]Ga-DOTA-3P-TATE-RGD PET/CT demonstrated divergent uptake patterns. Rebiopsy of the nodule with discordant tracer uptake confirmed squamous cell carcinoma, indicating synchronous double primary lung cancers. The dual-targeted tracer PET/CT guided precise biopsy and individualized therapy.

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